Rabies Vaccine Potency and Stability Testing

1988 ◽  
pp. 187-193
Author(s):  
Morag Ferguson ◽  
Valerie Seagroatt ◽  
G. C. Schild
Keyword(s):  
Rabies Vaccine ◽  
Stability Testing ◽  
Vaccine Potency

Replacement of in vivo human rabies vaccine potency testing by in vitro glycoprotein quantification using ELISA – Results of an international collaborative study

Vaccine ◽  
2017 ◽  
Vol 35 (6) ◽  
pp. 966-971 ◽  
Author(s):  
Sylvie Morgeaux ◽  
Bertrand Poirier ◽  
C. Ian Ragan ◽  
Dianna Wilkinson ◽  
Ulrich Arabin ◽  
...  
Keyword(s):  
Collaborative Study ◽  
Rabies Vaccine ◽  
Human Rabies ◽  
Vaccine Potency ◽  
International Collaborative ◽  
International Collaborative Study

Current Status of Rabies Vaccine Potency Testing

1985 ◽  
pp. 305-311
Author(s):  
M. Ferguson ◽  
G. C. Schild
Keyword(s):  
Rabies Vaccine ◽  
Current Status ◽  
Vaccine Potency

Appraisal of rabies vaccine potency by determination of in vitro, specific interleukin-2 production

Biologicals ◽  
1991 ◽  
Vol 19 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Marie-Line Joffret ◽  
Carlos Zanetti ◽  
Sylvie Morgeaux ◽  
Claude Leclerc ◽  
Pierre Sureau ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Rabies Vaccine ◽  
Vaccine Potency

Development of a Time and Cost Benefit Antibody Binding Test-Based Method for Determination of Rabies Vaccine Potency

2017 ◽  
Vol 30 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Vahid Asgary ◽  
Nazanin Mojtabavi ◽  
Alireza Janani ◽  
Tahereh Mousavi ◽  
Jamshid Hadjati ◽  
...  
Keyword(s):  
Cost Benefit ◽  
Rabies Vaccine ◽  
Antibody Binding ◽  
Vaccine Potency

scholarly journals A time-resolved fluoroimmunoassay to assay the rabies virus glycoprotein: application for estimation of human rabies vaccine potency

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Guanfeng Lin ◽  
Shaolang Chen ◽  
Hui Zhao ◽  
Junyu Liang ◽  
Qiaoting Deng ◽  
...  
Keyword(s):  
Rabies Virus ◽  
Rabies Vaccine ◽  
Human Rabies ◽  
Time Resolved ◽  
Rabies Virus Glycoprotein ◽  
Virus Glycoprotein ◽  
Vaccine Potency

scholarly journals Evaluation of Different Stabilizers and Inactivating Compounds for the Enhancement of Vero Cell Rabies Vaccine Stability and Immunogenicity:In VitroStudy

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Ebtesam Olayan ◽  
Manal El-Khadragy ◽  
Aly Fahmy Mohamed ◽  
Amany Khalil Mohamed ◽  
Rania Ibrahim Shebl ◽  
...  
Keyword(s):  
Rabies Virus ◽  
Human Albumin ◽  
Rabies Vaccine ◽  
World Health ◽  
Vaccine Preparation ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Vaccine Potency ◽  
Plasma Substitute ◽  
Health Organization

Inactivation of rabies virus is essential for rabies vaccine preparation where the inactivating compound that is currently recommended for rabies vaccine preparation isβ-propiolactone (β-PL). This compound is considered better than phenol and formalin but it is expensive and potentially carcinogenic. Data revealed that Ascorbic acid (AA) with cupric ions could yield complete and irreversible inactivation of rabies virus without adversely affecting its antigenicity. Additionally, the results of testing the vaccine potency with the selected inactivating compounds were comparable (P<0.05), and ED50was higher than the recommended World Health Organization (WHO) limits. The use of HemaGel (plasma substitute) for testing vaccine stabilization was compared with the currently used vaccine stabilizers (human albumin and lactose). HemaGel yielded better stability than the other tested stabilizers. Monitoring of cellular and humoral immune responses indicated that both the total IgG level against rabies vaccine and the IFN and IL5 levels obtained with the HemaGel-stabilized vaccines were higher than those obtained with human albumin- and lactose-stabilized vaccine candidates.

Replacing the NIH test for rabies vaccine potency testing: A synopsis of drivers and barriers

Biologicals ◽  
2014 ◽  
Vol 42 (4) ◽  
pp. 205-217 ◽  
Author(s):  
Marie-Jeanne Schiffelers ◽  
Bas Blaauboer ◽  
Wieger Bakker ◽  
Coenraad Hendriksen
Keyword(s):  
Rabies Vaccine ◽  
Vaccine Potency

scholarly journals Rabies vaccine potency control: comparison of ELISA systems for antigenicity testing

1996 ◽  
Vol 58 (1-2) ◽  
pp. 111-119 ◽  
Author(s):  
E.J.M. Rooijakkers ◽  
J.P. Uittenbogaard ◽  
J. Groen ◽  
A.D.M.E. Osterhaus
Keyword(s):  
Rabies Vaccine ◽  
Vaccine Potency ◽  
Control Comparison

Possibility of Immediate Introduction of a Single-Dose Antibody Induction Test as a Refinement of the NIH Test for Inactivated Rabies Vaccine Potency Determination

2020 ◽  
Vol 33 (5) ◽  
pp. 367-377
Author(s):  
Srđan Stankov ◽  
Nemanja Obradović ◽  
Dragana Vujin ◽  
Nenad Vranješ
Keyword(s):  
Single Dose ◽  
Rabies Vaccine ◽  
Vaccine Potency ◽  
Antibody Induction
Sign in / Sign up

Export Citation Format

Share Document