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2022 ◽  
Author(s):  
Pavel Filip ◽  
Petr Bednarik ◽  
Lynn E. Eberly ◽  
Amir Moheet ◽  
Alena Svatkova ◽  
...  

Bone ◽  
2022 ◽  
Vol 154 ◽  
pp. 116183
Author(s):  
Alex Ireland ◽  
Amy Riddell ◽  
Ann Prentice ◽  
Judith Eelloo ◽  
M. Zulf Mughal ◽  
...  

2021 ◽  
pp. 105477382110640
Author(s):  
Iman Al Hashmi ◽  
Atika Khalaf ◽  
Vidya Seshan ◽  
Hilal Alsabti ◽  
Omar Al Omari ◽  
...  

The purpose of this retrospective, matched case-control study (two controls [healthy control and high- risk control] vs. COVID-19 cases) was to compare the maternal and neonatal outcomes of pregnant women with and without COVID-19. A total of 261 pregnant women from three different countries with and without COVID-19 were included in this study. Several pregnancy complications were more common in high-risk pregnant women compared to COVID-19 cases and healthy pregnant women. These include preeclampsia ( p < .01), vaginal bleeding ( p < .05), preterm labor ( p < .05), premature rupture of membrane ( p < .01), requiring induction of labor ( p < .05), have lower gestational age on delivery ( F (2) = 3.1, p < .05), requiring cesarean section ( p < .01), neonatal admission in the NICU ( p < .01), and low neonatal Apgar score ( p < .01). Nurses are advised to provide equal attention to pregnant women with underlying health issues and to pregnant women infected with COVID-19 in terms of the risk assessment, health care, and follow-up for optimal maternal and neonatal outcomes.


Author(s):  
David B Neale ◽  
Aleksey V Zimin ◽  
Sumaira Zaman ◽  
Alison D Scott ◽  
Bikash Shrestha ◽  
...  

Abstract Sequencing, assembly, and annotation of the 26.5 Gbp hexaploid genome of coast redwood (Sequoia sempervirens) was completed leading toward discovery of genes related to climate adaptation and investigation of the origin of the hexaploid genome. Deep-coverage short-read Illumina sequencing data from haploid tissue from a single seed were combined with long-read Oxford Nanopore Technologies sequencing data from diploid needle tissue to create an initial assembly, which was then scaffolded using proximity ligation data to produce a highly contiguous final assembly, SESE 2.1, with a scaffold N50 size of 44.9 Mbp. The assembly included several scaffolds that span entire chromosome arms, confirmed by the presence of telomere and centromere sequences on the ends of the scaffolds. The structural annotation produced 118,906 genes with 113 containing introns that exceed 500 Kbp in length and one reaching 2 Mb. Nearly 19 Gbp of the genome represented repetitive content with the vast majority characterized as long terminal repeats, with a 2.9:1 ratio of Copia to Gypsy elements that may aid in gene expression control. Comparison of coast redwood to other conifers revealed species-specific expansions for a plethora of abiotic and biotic stress response genes, including those involved in fungal disease resistance, detoxification, and physical injury/structural remodeling and others supporting flavonoid biosynthesis. Analysis of multiple genes that exist in triplicate in coast redwood but only once in its diploid relative, giant sequoia, supports a previous hypothesis that the hexaploidy is the result of autopolyploidy rather than any hybridizations with separate but closely related conifer species.


2021 ◽  
pp. annrheumdis-2021-221267
Author(s):  
Yoshihiko Tomofuji ◽  
Toshihiro Kishikawa ◽  
Yuichi Maeda ◽  
Kotaro Ogawa ◽  
Takuro Nii ◽  
...  

ObjectiveThe relationship between autoimmune diseases and the gut microbiome has been intensively studied, and several autoimmunity-associated bacterial taxa have been identified. However, much less is known about the roles of the gut virome in autoimmune diseases.MethodsHere, we performed a whole gut virome analysis based on the shotgun sequencing of 476 Japanese which included patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis and healthy control subjects.ResultsOur case–control comparison of the viral abundance revealed that crAss-like phages, which are one of the main components of a healthy gut virome, significantly decreased in the gut of the patients with autoimmune disease, specifically the patients with RA and SLE. In addition, Podoviridae significantly decreased in the gut of the patients with SLE. To understand how these viruses affected the bacteriome, we performed a quantitative virus–bacterium association analysis and clustered regularly interspaced short palindromic repeat-based virus–bacterium interaction analysis. We identified a symbiosis between Podoviridae and Faecalibacterium. In addition, multiple bacterial targets of crAss-like phages were identified (eg, Ruminococcus spp).ConclusionOur data suggest that the gut virome can affect our body either directly or via bacteria. Our analyses have elucidated a previously missing part of the autoimmunity-associated gut microbiome and presented new candidates that contribute to the development of autoimmune diseases.


2021 ◽  
Author(s):  
Anuli C Uzozie ◽  
Theodore G Smith ◽  
Siyuan Chen ◽  
Philipp F Lange

The cleavage-site specificities for many proteases are not well-understood, restricting the utility of supervised classification methods. We present an algorithm and web interface to overcome this limitation through the unsupervised detection of overrepresented patterns in protein sequence data, providing insight into the mixture of protease activities contributing to a complex system. Here, we apply the RObust LInear Motif Deconvolution (RoLiM) algorithm to confidently detect substrate cleavage patterns for SARS-CoV-2 Mpro protease in N terminome data of an infected human cell line. Using mass spectrometry-based peptide data from a case-control comparison of 341 primary urothelial bladder cancer cases and 110 controls, we identified distinct sequence motifs indicative of increased MMP activity in urine from cancer patients. Evaluation of N terminal peptides from patient plasma post-chemotherapy detected novel Granzyme B/Corin activity. RoLiM will enhance unbiased investigation of peptide sequences to establish the composition of known and uncharacterized protease activities in biological systems.


2021 ◽  
Author(s):  
Gena Nelson ◽  
Hannah Carter ◽  
Peter Boedeker

The purpose of document is to provide readers with the coding protocol that authors used to code experimental and quasi-experimental early mathematics intervention studies conducted in informal learning environments. The studies were conducted in homes and in museums with caregivers as intervention agents and included children between the ages of 3,0 and 8,11 years. The coding protocol includes more than 200 variables related to basic study information, participant sample size and demographics, methodological information, intervention information, mathematics content information, the control/comparison condition, outcome measures, and results and effect sizes. The coding protocol was developed for the purpose of conducting a meta-analysis; results of the meta-analysis is pending. The data set associated with this coding protocol will be available to the public at the conclusion of the grant (early 2024).


2021 ◽  
Author(s):  
◽  
Gillian Chell Hubbard

<p>Shakespeare's Hamlet, like Spenser's The Faerie Queene Book II, is a work systematically concerned with the virtue of temperance. This conclusion is reached partly from comparison between Spenser and Shakespeare. But I also set their works in the context of a range of relevant sources available to the Early Modern period. While comparisons between aspects of FQII and Hamlet are not unknown, critical attention to their common foundation in temperance has been limited. Like Spenser in FQII, Shakespeare in Hamlet is concerned with a virtue that has its roots in the interconnected Greek precepts "Know Thyself", "Nothing in Excess' and "Think Mortal Thoughts." To be sophron (temperate) is to live in accordance with these precepts. Spenser presents the opposed vice of intemperance through the excesses of avarice and lust in the Cave of Mammon and the Bower of Bliss. Shakespeare portrays a court in Elsinore where excess, irascibility, lust and avarice for power are barely concealed beneath a veneer of Ciceronian social decorum and a didactic commitment to self-control. Comparison with the varied aspects of temperance in FQII makes clear how constantly and variously Hamlet reflects upon temperance and intemperance. There is an underlying tension in both FQII and Hamlet between traditional ideals of moderation and self-control on the one hand, and imagery and archetypes of the Fall and tainted human nature on the other. This tension arises naturally in a treatment of a virtue which, although it derives from classical thought, was carefully assimilated into Christian theology by the Church Fathers. As in much Early Modern writing, we find strands of Platonic, Aristotelian and Stoic thought that privilege reason (on the one hand) intermingled with (on the other) an Augustinian emphasis on the heart, the will, and dependence on Christian grace. In Hamlet Shakespeare portrays Claudius as one intractably intemperate in the Aristotelian sense, a condition made apparent in his inability to repent. Claudius' apparent rational self-control is based on premises that are ultimately false; his actions therefore derive from "false prudence" as defined by Aquinas. His projection of reasonableness forces his antagonist, Hamlet, into a range of irascible and irrational behaviour, some of which is calculated and some of which is not. Both Spenser and Shakespeare present an anatomy of the processes of rational self-control and their disruption by the passions. Both are also concerned with the metaphysical dimensions of temperance, both Platonic and Pauline. When Hamlet (like a Greek sophronistes) sees it as his duty to act against Claudius, "this canker of our nature," he is expressing a confused mixture of desires--for ethical and spiritual transformation, political reformation, justice, and an irascible lust for vengeance. It is no coincidence that the problematic endings of both FQII and Hamlet echo the conclusion of the Aeneid and its failure to reconcile justice and temperance.</p>


2021 ◽  
Author(s):  
◽  
Gillian Chell Hubbard

<p>Shakespeare's Hamlet, like Spenser's The Faerie Queene Book II, is a work systematically concerned with the virtue of temperance. This conclusion is reached partly from comparison between Spenser and Shakespeare. But I also set their works in the context of a range of relevant sources available to the Early Modern period. While comparisons between aspects of FQII and Hamlet are not unknown, critical attention to their common foundation in temperance has been limited. Like Spenser in FQII, Shakespeare in Hamlet is concerned with a virtue that has its roots in the interconnected Greek precepts "Know Thyself", "Nothing in Excess' and "Think Mortal Thoughts." To be sophron (temperate) is to live in accordance with these precepts. Spenser presents the opposed vice of intemperance through the excesses of avarice and lust in the Cave of Mammon and the Bower of Bliss. Shakespeare portrays a court in Elsinore where excess, irascibility, lust and avarice for power are barely concealed beneath a veneer of Ciceronian social decorum and a didactic commitment to self-control. Comparison with the varied aspects of temperance in FQII makes clear how constantly and variously Hamlet reflects upon temperance and intemperance. There is an underlying tension in both FQII and Hamlet between traditional ideals of moderation and self-control on the one hand, and imagery and archetypes of the Fall and tainted human nature on the other. This tension arises naturally in a treatment of a virtue which, although it derives from classical thought, was carefully assimilated into Christian theology by the Church Fathers. As in much Early Modern writing, we find strands of Platonic, Aristotelian and Stoic thought that privilege reason (on the one hand) intermingled with (on the other) an Augustinian emphasis on the heart, the will, and dependence on Christian grace. In Hamlet Shakespeare portrays Claudius as one intractably intemperate in the Aristotelian sense, a condition made apparent in his inability to repent. Claudius' apparent rational self-control is based on premises that are ultimately false; his actions therefore derive from "false prudence" as defined by Aquinas. His projection of reasonableness forces his antagonist, Hamlet, into a range of irascible and irrational behaviour, some of which is calculated and some of which is not. Both Spenser and Shakespeare present an anatomy of the processes of rational self-control and their disruption by the passions. Both are also concerned with the metaphysical dimensions of temperance, both Platonic and Pauline. When Hamlet (like a Greek sophronistes) sees it as his duty to act against Claudius, "this canker of our nature," he is expressing a confused mixture of desires--for ethical and spiritual transformation, political reformation, justice, and an irascible lust for vengeance. It is no coincidence that the problematic endings of both FQII and Hamlet echo the conclusion of the Aeneid and its failure to reconcile justice and temperance.</p>


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