Resolution and Limitations in Biological Applications of Atomic Force Microscopy

1994 ◽  
pp. 43-51
Author(s):  
Jie Yang ◽  
Lukas K. Tamm ◽  
Zhifeng Shao
Keyword(s):  
Atomic Force Microscopy ◽  
Biological Applications ◽  
Force Microscopy ◽  
Atomic Force

scholarly journals Routine and Timely Sub-Piconewton Force Stability and Precision for Biological Applications of Atomic Force Microscopy

2013 ◽  
Vol 104 (2) ◽  
pp. 211a
Author(s):  
Allison B. Churnside ◽  
Ruby May A. Sullan ◽  
Duc M. Nguyen ◽  
Matthew S. Bull ◽  
Gavin M. King ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Biological Applications ◽  
Force Microscopy ◽  
Atomic Force

scholarly journals Routine and Timely Sub-picoNewton Force Stability and Precision for Biological Applications of Atomic Force Microscopy

Nano Letters ◽  
2012 ◽  
Vol 12 (7) ◽  
pp. 3557-3561 ◽  
Author(s):  
Allison B. Churnside ◽  
Ruby May A. Sullan ◽  
Duc M. Nguyen ◽  
Sara O. Case ◽  
Matthew S. Bull ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Biological Applications ◽  
Force Microscopy ◽  
Atomic Force

scholarly journals Atomic force microscopy with sub-picoNewton force stability for biological applications

Methods ◽  
2013 ◽  
Vol 60 (2) ◽  
pp. 131-141 ◽  
Author(s):  
Ruby May A. Sullan ◽  
Allison B. Churnside ◽  
Duc M. Nguyen ◽  
Matthew S. Bull ◽  
Thomas T. Perkins
Keyword(s):  
Atomic Force Microscopy ◽  
Biological Applications ◽  
Force Microscopy ◽  
Atomic Force

scholarly journals Study of Probes and Substrates for Low Temperature Atomic Force Microscopy and Biological Applications

2003 ◽  
Vol 104 (3-4) ◽  
pp. 373-380
Author(s):  
A. Radenovic ◽  
E. Bystrenova ◽  
L. Libioulle ◽  
G. Dietler
Keyword(s):  
Atomic Force Microscopy ◽  
Low Temperature ◽  
Biological Applications ◽  
Force Microscopy ◽  
Atomic Force

Subnanometer-scale imaging of nanobio-interfaces by frequency modulation atomic force microscopy

2020 ◽  
Vol 48 (4) ◽  
pp. 1675-1682
Author(s):  
Takeshi Fukuma
Keyword(s):  
Atomic Force Microscopy ◽  
Frequency Modulation ◽  
Critical Role ◽  
Surface Structures ◽  
Scale Model ◽  
Dynamic Mode ◽  
Biological Applications ◽  
Scanning Method ◽  
Force Microscopy ◽  
Atomic Force

Recently, there have been significant advancements in dynamic-mode atomic force microscopy (AFM) for biological applications. With frequency modulation AFM (FM-AFM), subnanometer-scale surface structures of biomolecules such as secondary structures of proteins, phosphate groups of DNAs, and lipid-ion complexes have been directly visualized. In addition, three-dimensional AFM (3D-AFM) has been developed by combining a high-resolution AFM technique with a 3D tip scanning method. This method enabled visualization of 3D distributions of water (i.e. hydration structures) with subnanometer-scale resolution on various biological molecules such as lipids, proteins, and DNAs. Furthermore, 3D-AFM also allows visualization of subnanometer-scale 3D distributions of flexible surface structures such as thermally fluctuating lipid headgroups. Such a direct local information at nano-bio interfaces can play a critical role in determining the atomic- or molecular-scale model to explain interfacial structures and functions. Here, we present an overview of these recent advancements in the dynamic-mode AFM techniques and their biological applications.

scholarly journals Development and testing of hyperbaric atomic force microscopy (AFM) for biological applications

2010 ◽  
Vol 16 (S2) ◽  
pp. 1042-1043 ◽  
Author(s):  
D D'Agostino ◽  
D Jay ◽  
H McNally
Keyword(s):  
Atomic Force Microscopy ◽  
Biological Applications ◽  
Force Microscopy ◽  
Atomic Force

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.

INVITED PAPER: Instrumentation and Biological Applications of High-Resolution Frequency Modulation Atomic Force Microscopy in Liquid

2009 ◽  
Vol 4 ◽  
pp. 1-10 ◽  
Author(s):  
Takeshi Fukuma
Keyword(s):  
Atomic Force Microscopy ◽  
Frequency Modulation ◽  
Recent Progress ◽  
Imaging Techniques ◽  
Alkali Halides ◽  
Atomic Scale ◽  
Biological Applications ◽  
Force Microscopy ◽  
Organic Systems ◽  
Atomic Force

Frequency modulation atomic force microscopy (FM-AFM) has been a powerful tool for imaging atomic-scale structures and properties of various materials including metals, semiconductors, metal oxides, alkali halides and organic systems. Whilst the method has been used mainly in ultrahigh vacuum environments, recent progress in FM-AFM instrumentation made it possible to apply this technique also to investigations in liquid. This technological innovation opened up a variety of applications of FM-AFM in biology and electrochemistry. To date, the improved FM-AFM instrument and technique have been applied to investigations of several biological materials, providing novel information that has not been accessible with other imaging techniques. In this review, I will summarize the recent progress in FM-AFM instrumentation and biological applications in liquid.

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