With the development of e-commerce technology and mobile communications technology, a new business model is emerged, which is the mobile e-commerce. It is flexible and convenient, without time and geographical constraints, so it has a huge market potential. In this paper, the program development of android mobile phones and mobile e-commerce architecture are studied. First, the mobile e-commerce and Android system are introduced, and then mobile e-commerce architecture and android application development are studied, the key technology in mobile e-commerce is researched and discussed.