Hepatitis B Surface Antigen Polypeptide and Synthetic Peptide Vaccines

Hepatitis B ◽  
1984 ◽  
pp. 215-224 ◽  
Author(s):  
G. R. Dreesman ◽  
I. Ionescu-Matiu ◽  
Y. Sanchez ◽  
R. C. Kennedy ◽  
J. T. Sparrow ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Synthetic Peptide ◽  
Hepatitis B Surface Antigen ◽  
Peptide Vaccines

IMMUNOGENICITY OF HEPATITIS B SURFACE ANTIGEN SYNTHETIC PEPTIDE ANALOGUES

1987 ◽  
pp. 565-568
Author(s):  
B. Lammek ◽  
G. Kupryszewski ◽  
U. Ragnarsson ◽  
H. Świderska ◽  
M. Jastrzebska ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Synthetic Peptide ◽  
Hepatitis B Surface Antigen ◽  
Peptide Analogues

scholarly journals Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.

1983 ◽  
Vol 46 (2) ◽  
pp. 653-655 ◽  
Author(s):  
R C Kennedy ◽  
G R Dreesman ◽  
J T Sparrow ◽  
A R Culwell ◽  
Y Sanchez ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Synthetic Peptide ◽  
Hepatitis B Surface Antigen

scholarly journals Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant.

1982 ◽  
Vol 79 (14) ◽  
pp. 4400-4404 ◽  
Author(s):  
P. K. Bhatnagar ◽  
E. Papas ◽  
H. E. Blum ◽  
D. R. Milich ◽  
D. Nitecki ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Synthetic Peptide ◽  
Hepatitis B Surface Antigen ◽  
Peptide Analogues

scholarly journals Molecular mimicry of hepatitis B surface antigen by an anti-idiotype-derived synthetic peptide.

1992 ◽  
Vol 89 (24) ◽  
pp. 11900-11904 ◽  
Author(s):  
M. W. Pride ◽  
H. Shi ◽  
J. M. Anchin ◽  
D. S. Linthicum ◽  
P. T. LoVerde ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Synthetic Peptide ◽  
Molecular Mimicry ◽  
Hepatitis B Surface Antigen

scholarly journals Nonoverlapping T and B cell determinants on an hepatitis B surface antigen pre-S(2) region synthetic peptide.

1986 ◽  
Vol 164 (2) ◽  
pp. 532-547 ◽  
Author(s):  
D R Milich ◽  
A McLachlan ◽  
F V Chisari ◽  
G B Thornton
Keyword(s):  
T Cell ◽  
Hepatitis B ◽  
B Cell ◽  
Surface Antigen ◽  
Synthetic Peptide ◽  
Hepatitis B Surface Antigen ◽  
Cell Recognition ◽  
Terminal Sequence ◽  
T Cell Recognition ◽  
Recognition Sites

We have examined T cell recognition of a hepatitis B surface antigen (HBsAg), pre-S(2)-region synthetic peptide, p120-145, in terms of fine specificity, H-2-linked genetic influences, comparison to antibody binding, and relevance to T cell recognition of the native protein. We showed that the immune response to the synthetic peptide is regulated by H-2-linked genes, but that the pattern of H-2 restriction differed from that observed for the native anti-pre-S(2) response. Dominant and nonoverlapping T cell and B cell recognition sites were identified on the synthetic peptide p120-145. T cell recognition is focussed on the NH2-terminal sequence, and antibody (B cell) recognition is focussed on the COOH-terminal sequence. The fine specificity of T cell recognition of p120-145 was defined by a single, subtype-dependent amino acid substitution. With respect to the immunogenicity of p120-145, the synthetic peptide containing both T and B cell determinants is highly immunogenic in responder strains, whereas separate T or B cell peptide determinants are minimally immunogenic. Furthermore, the synthetic T cell recognition site can prime T cell help for antibody production to the synthetic B cell site, which is crossreactive with the native pre-S(2) region of HBsAg/p33 particles. This system provides evidence that totally synthetic T cell and B cell recognition sites can be combined to yield a functional immunogen.

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