Regulation of Angiotensin II Receptor Expression in Ovarian Follicles

Author(s):  
A. H. Nielsen ◽  
A. Hagemann ◽  
B. Svenstrup ◽  
J. Nielsen ◽  
K. Poulsen
2013 ◽  
Vol 19 (17) ◽  
pp. 3013-3021 ◽  
Author(s):  
Toshihiro Ichiki

1998 ◽  
Vol 3 (2) ◽  
pp. 121-130 ◽  
Author(s):  
Baichun Yang ◽  
Dayuan Li ◽  
M Ian Phillips ◽  
Paulette Mehta ◽  
Jawahar L Mehta

2008 ◽  
Vol 63 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Charles R Rosenfeld ◽  
Alexander M Zagariya ◽  
Xiao-Tie Liu ◽  
Brigham C Willis ◽  
Steven Fluharty ◽  
...  

2009 ◽  
Vol 89 (2) ◽  
pp. 164-177 ◽  
Author(s):  
Akiko Mii ◽  
Akira Shimizu ◽  
Yukinari Masuda ◽  
Masamichi Ishizaki ◽  
Hiroshi Kawachi ◽  
...  

1994 ◽  
Vol 21 (6) ◽  
pp. 463-469 ◽  
Author(s):  
A. H. Nielsen ◽  
A. Hagemann ◽  
B. Svenstrup ◽  
J. Nielsen ◽  
K. Poulsen

2011 ◽  
Vol 31 (3) ◽  
pp. 291-300 ◽  
Author(s):  
Niko Braun ◽  
Peter Fritz ◽  
Dagmar Biegger ◽  
Martin Kimmel ◽  
Fabian Reimold ◽  
...  

ObjectiveEncapsulating peritoneal sclerosis (EPS) is a rare but life-threatening complication of peritoneal dialysis (PD). The optimal management of patients with EPS is uncertain. In the present study, we investigated differences in the expression of nuclear receptors [progesterone (PR), androgen (AR), vitamin D (VDR), and glucocorticoid (GCR)] in the human peritoneum. We also investigated estrogen receptor (ER), matrix metalloproteinase 9 (MMP9), and transforming growth factor β1 (TGFβ1) in the context of their potential role in tamoxifen therapy.MethodsWe analyzed clinical and histologic characteristics of 72 peritoneal biopsy specimens (22 from EPS patients, 11 from PD patients, 15 from uremic patients, and 24 from control subjects undergoing hernia repair). For immunophenotyping, we used antibodies against VDR, GCR, ER, PR, AR, MMP9, and TGFβ1.ResultsIn human peritoneum, VDR and GCR are highly expressed (98.6% and 87.3% respectively). Except in the case of VDR ( p = 0.0012), we observed no significant difference in receptor expression between the groups. Expression of ER and PR was sparse (11.4% and 31% respectively), with higher expression in women, and AR was absent. Minimal MMP9 expression and moderate TGFβ1 expression were observed in all groups. The differences between the groups were nonsignificant.ConclusionsNuclear receptors are present in human peritoneum. Except in the case of VDR, the pattern for any one group is nonspecific. Glucocorticoids, vitamin D, and angiotensin converting-enzyme inhibitors or angiotensin II receptor blockers (via the vitamin D/angiotensin II pathway) might be suitable interventions for preservation of the integrity of the peritoneal membrane. The mechanism of action of tamoxifen is still not elucidated, ER expression in the peritoneum is sparse, and data about the studied pathways (MMP9, TGFβ) are inconsistent.


Hypertension ◽  
1998 ◽  
Vol 32 (3) ◽  
pp. 527-533 ◽  
Author(s):  
Makoto Usui ◽  
Toshihiro Ichiki ◽  
Makoto Katoh ◽  
Kensuke Egashira ◽  
Akira Takeshita

2000 ◽  
Vol 22 (3) ◽  
pp. 323-332 ◽  
Author(s):  
Catherine Chassagne ◽  
Saadia Eddahibi ◽  
Christophe Adamy ◽  
Dominique Rideau ◽  
Françoise Marotte ◽  
...  

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