Open and Stereotactic Segmental Callosotomy: Effects on Seizure Frequency

1995 ◽  
pp. 209-215 ◽  
Author(s):  
Raul Marino ◽  
Arthur Cukiert ◽  
Gary Gronich
Keyword(s):  
Seizure Frequency

Everolimus Reduces Seizure Frequency in Tuberous Sclerosis Complex

2017 ◽  
Vol 48 (S 01) ◽  
pp. S1-S45
Author(s):  
T. Stapper ◽  
D. Valcheva ◽  
T. Höll ◽  
T. Rosenbaum
Keyword(s):  
Tuberous Sclerosis ◽  
Seizure Frequency ◽  
Tuberous Sclerosis Complex

Concordance between the interictal focal EEG pattern and MRI lesions as a predictor of a favorable surgical outcome in patients with epileptic spasms: a Chinese study

2019 ◽  
Vol 23 (4) ◽  
pp. 422-431 ◽  
Author(s):  
Cuiping Xu ◽  
Tao Yu ◽  
Guojun Zhang ◽  
Gary B. Rajah ◽  
Yuping Wang ◽  
...  
Keyword(s):  
Seizure Frequency ◽  
Surgical Outcome ◽  
Epileptic Spasms ◽  
Select Group ◽  
Chinese Study ◽  
Interictal Eeg ◽  
Atypical Absence ◽  
Multilobar Resection ◽  
Age Range ◽  
Eeg Pattern

OBJECTIVEThe aim of this study was to evaluate the electro-clinical features, etiology, treatment, and postsurgical seizure outcomes in patients with intractable epileptic spasms (ESs).METHODSThe authors retrospectively studied the medical records of all patients who had presented with medically intractable ESs and had undergone surgery in the period between October 2009 and August 2015. The interictal electroencephalography (EEG) pattern, MRI studies, magnetoencephalography findings, and postsurgical seizure outcomes were compared.RESULTSTwenty-six patients, 12 boys and 14 girls (age range 3–22 years), were eligible for study inclusion. Of these 26 patients, 84.6% (22) presented with multiple seizure types including partial seizures (PSs) independent of the ESs (30.8%); ESs followed by tonic seizures (30.8%); myoclonic seizures (19.2%); tonic seizures (19.2%); ESs followed by PSs (19.2%); focal seizures with secondary generalization (15.4%); atypical absence (11.5%); PSs followed by ESs (7.7%); and myoclonic followed by tonic seizures (7.7%). Seventeen patients underwent multilobar resection and 9 underwent unilobar resection. At the last follow-up (mean 36.6 months), 42.3% of patients were seizure free (outcome classification [OC] 1), 23.1% had > 50% reduction in seizure frequency (OC2–OC4), and 34.6% had < 50% reduction in seizure frequency or no improvement (OC5 and OC6). Predictors of favorable outcomes included an interictal focal EEG pattern and concordance between interictal EEG and MRI-demonstrated lesions (p = 0.001 and 0.004, respectively).CONCLUSIONSA favorable surgical outcome is achievable in a highly select group of patients with ESs secondary to structural lesions. Interictal EEG can help in identifying patients with the potential for favorable resective outcomes.

scholarly journals Seizure frequency discrepancy between subjective and objective ictal electroencephalography data in dogs

2021 ◽  
Author(s):  
Masayasu Ukai ◽  
Thomas Parmentier ◽  
Miguel A. Cortez ◽  
Andrea Fischer ◽  
Luis Gaitero ◽  
...  
Keyword(s):  
Seizure Frequency

THE EFFECT OF QUARANTINE DUE TO COVID-19 PANDEMIC ON SEIZURE FREQUENCY IN 102 ADULT PEOPLE WITH EPILEPSY FROM APULIA AND BASILICATA REGIONS, SOUTHERN ITALY

2021 ◽  
pp. 106592
Author(s):  
Giuseppe d’Orsi ◽  
Francesca Mazzeo ◽  
Domenico Ravidà ◽  
Maria Teresa Di Claudio ◽  
Annarita Sabetta ◽  
...  
Keyword(s):  
Seizure Frequency ◽  
Southern Italy

Vagus nerve stimulation for drug-resistant epilepsy

2019 ◽  
Vol 20 (3) ◽  
pp. 189-198 ◽  
Author(s):  
Laura Pérez-Carbonell ◽  
Howard Faulkner ◽  
Sean Higgins ◽  
Michalis Koutroumanidis ◽  
Guy Leschziner
Keyword(s):  
Vagus Nerve ◽  
Seizure Frequency ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Therapeutic Option ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy ◽  
Randomised Controlled

Vagus nerve stimulation (VNS) is a neuromodulatory therapeutic option for drug-resistant epilepsy. In randomised controlled trials, VNS implantation has resulted in over 50% reduction in seizure frequency in 26%–40% of patients within 1 year. Long-term uncontrolled studies suggest better responses to VNS over time; however, the assessment of other potential predictive factors has led to contradictory results. Although initially designed for managing focal seizures, its use has been extended to other forms of drug-resistant epilepsy. In this review, we discuss the evidence supporting the use of VNS, its impact on seizure frequency and quality of life, and common adverse effects of this therapy. We also include practical guidance for the approach to and the management of patients with VNS in situ.

Vagus nerve stimulation for complex partial seizures: surgical technique, safety, and efficacy

1993 ◽  
Vol 78 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Howard J. Landy ◽  
R. Eugene Ramsay ◽  
Jeremy Slater ◽  
Roy R. Casiano ◽  
Robert Morgan
Keyword(s):  
Vagus Nerve ◽  
Vocal Cord ◽  
Seizure Frequency ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Vocal Cord Dysfunction ◽  
High Current ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Stimulation Group

✓ Electrical stimulation of the vagus nerve has shown efficacy in controlling seizures in experimental models, and early clinical trials have suggested possible benefit in humans. Eleven patients with complex partial seizures were subjected to implantation of vagus nerve stimulators. Electrode contacts embedded in silicone rubber spirals were placed on the left vagus nerve in the low cervical area. A transcutaneously programmable stimulator module was placed in an infraclavicular subcutaneous pocket and connected to the electrode. One patient required replacement of the system due to electrode fracture. Another patient developed delayed ipsilateral vocal-cord paralysis; the technique was then modified to allow more tolerance for postoperative nerve edema. A third patient showed asymptomatic vocal-cord paresis on immediate postoperative laryngoscopy. Vagus nerve stimulation produces transient vocal-cord dysfunction while the current is on. Nine patients were randomly assigned to receive either high- or low-current stimulation, and seizure frequency was recorded. The high-current stimulation group showed a median reduction in seizure frequency of 27.7% compared to the preimplantation baseline, while the low-current stimulation group showed a median increase of 6.3%. This difference approached statistical significance. The entire population then received maximally tolerable stimulation. The high-current stimulation group showed a further 14.3% reduction, while the low-current stimulation group showed a 25.4% reduction compared to the blinded period. The efficacy of vagus nerve stimulation seemed to depend on stimulus parameters, and a cumulative effect was evident. These results are encouraging, and further study of this modality as an adjunct treatment for epilepsy is warranted.

Seizure severity is associated with quality of life independent of seizure frequency

2009 ◽  
Vol 16 (2) ◽  
pp. 325-329 ◽  
Author(s):  
Ramon Edmundo D. Bautista ◽  
E. Tannahill Glen
Keyword(s):  
Quality Of Life ◽  
Seizure Frequency ◽  
Seizure Severity

Chronic Epileptic Foci in Monkeys: Correlation Between Seizure Frequency and Proportion of Pacemaker Epileptic Neurons

Epilepsia ◽  
1978 ◽  
Vol 19 (5) ◽  
pp. 475-483 ◽  
Author(s):  
Allen R. Wyler ◽  
Kim J. Burchiel ◽  
Arthur A. Ward
Keyword(s):  
Seizure Frequency
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