Approaches for Optimal Dose Selection for Adaptive Design Trials

2014 ◽  
pp. 125-137 ◽  
Author(s):  
David Lawrence ◽  
Frank Bretz
Keyword(s):  
Adaptive Design ◽  
Optimal Dose ◽  
Dose Selection ◽  
Selection For

Variation in Severity Assessment and Initial Mesalamine Dose Selection for Ulcerative Colitis in Community Practice

2006 ◽  
Vol 40 (7) ◽  
pp. 587-591 ◽  
Author(s):  
Bruce E. Sands ◽  
Karl M. Kilgore ◽  
Richard S. Bloomfeld ◽  
William J. Sandborn
Keyword(s):  
Ulcerative Colitis ◽  
Severity Assessment ◽  
Community Practice ◽  
Dose Selection ◽  
Selection For

scholarly journals Pharmacokinetic-Pharmacodynamic (PK-PD) Target Attainment (TA) Analyses Supporting Lefamulin Dose Selection for the Treatment of Patients With Community-Acquired Bacterial Pneumonia (CABP)

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Sujata M. Bhavnani ◽  
Paul G. Ambrose ◽  
Wolfgang W. Wicha ◽  
Zrinka Ivezic-Schoenfeld ◽  
William T. Prince ◽  
...  
Keyword(s):  
Bacterial Pneumonia ◽  
Target Attainment ◽  
Dose Selection ◽  
Selection For

Dose selection for prostate cancer patients based on dose comparison and dose response studies

2000 ◽  
Vol 46 (4) ◽  
pp. 823-832 ◽  
Author(s):  
Gerald E. Hanks ◽  
Alexandra L. Hanlon ◽  
Wayne H. Pinover ◽  
Eric M. Horwitz ◽  
Robert A. Price ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Dose Response ◽  
Dose Selection ◽  
Dose Comparison ◽  
Selection For

scholarly journals Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Sarah J. Mitchell ◽  
Alice E. Kane ◽  
Sarah N. Hilmer
Keyword(s):  
Older Adults ◽  
Hepatic Clearance ◽  
Optimal Dose ◽  
Interindividual Variation ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Dose Selection ◽  
Age Related ◽  
Accidental Overdose ◽  
Toxicity Of Drugs ◽  
Age Related Changes

Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults. Poor understanding of how hepatic clearance and toxicity are different with age results in suboptimal dose selection, poor efficacy, and/or increased toxicity. Of particular concern is the analgesic paracetamol which has been in use for more than 50 years and is consumed by a large proportion of older adults. Paracetamol is considered to be a relatively safe drug; however, caution must be taken because of its potential for toxicity. Paracetamol-induced liver injury from accidental overdose accounts for up to 55% of cases in older adults. Better understanding of how age affects the hepatic clearance and toxicity of drugs will contribute to evidence-based prescribing for older people, leading to fewer adverse drug reactions without loss of benefit.

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