Silicon Photonic Micro-Ring Resonators for Drug Screening and Kinetic Analysis

2015 ◽  
pp. 133-153
Author(s):  
Muzammil Iqbal ◽  
Rufus W. Burlingame ◽  
Randy Romero ◽  
Annabel Wang ◽  
Tyler Grove ◽  
...  
Keyword(s):  
Kinetic Analysis ◽  
Drug Screening ◽  
Ring Resonators ◽  
Silicon Photonic

scholarly journals Kinetic Analysis of Lidocaine Elimination by Pig Liver Cells Cultured in 3D Multi-Compartment Hollow Fiber Membrane Network Perfusion Bioreactors

2021 ◽  
Vol 8 (8) ◽  
pp. 104
Author(s):  
Gerardo Catapano ◽  
Juliane K. Unger ◽  
Elisabetta M. Zanetti ◽  
Gionata Fragomeni ◽  
Jörg C. Gerlach
Keyword(s):  
Kinetic Analysis ◽  
Drug Screening ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Liver Cells ◽  
Fiber Membrane ◽  
Bioreactor Design ◽  
Drug Adsorption ◽  
And Performance ◽  
Cells Cultured

Liver cells cultured in 3D bioreactors is an interesting option for temporary extracorporeal liver support in the treatment of acute liver failure and for animal models for preclinical drug screening. Bioreactor capacity to eliminate drugs is generally used for assessing cell metabolic competence in different bioreactors or to scale-up bioreactor design and performance for clinical or preclinical applications. However, drug adsorption and physical transport often disguise the intrinsic drug biotransformation kinetics and cell metabolic state. In this study, we characterized the intrinsic kinetics of lidocaine elimination and adsorption by porcine liver cells cultured in 3D four-compartment hollow fiber membrane network perfusion bioreactors. Models of lidocaine transport and biotransformation were used to extract intrinsic kinetic information from response to lidocaine bolus of bioreactor versus adhesion cultures. Different from 2D adhesion cultures, cells in the bioreactors are organized in liver-like aggregates. Adsorption on bioreactor constituents significantly affected lidocaine elimination and was effectively accounted for in kinetic analysis. Lidocaine elimination and cellular monoethylglicinexylidide biotransformation featured first-order kinetics with near-to-in vivo cell-specific capacity that was retained for times suitable for clinical assist and drug screening. Different from 2D cultures, cells in the 3D bioreactors challenged with lidocaine were exposed to close-to-physiological lidocaine and monoethylglicinexylidide concentration profiles. Kinetic analysis suggests bioreactor technology feasibility for preclinical drug screening and patient assist and that drug adsorption should be accounted for to assess cell state in different cultures and when laboratory bioreactor design and performance is scaled-up to clinical use or toxicological drug screening.

Silicon photonic devices for mid-infrared applications

Nanophotonics ◽  
2014 ◽  
Vol 3 (4-5) ◽  
pp. 329-341 ◽  
Author(s):  
Raji Shankar ◽  
Marko Lončar
Keyword(s):  
Gas Sensing ◽  
Wavelength Region ◽  
Photonic Devices ◽  
Ring Resonators ◽  
Space Communications ◽  
Mid Infrared ◽  
Silicon Photonic ◽  
Processing Techniques ◽  
Silicon Based

AbstractThe mid-infrared (IR) wavelength region (2–20 µm) is of great interest for a number of applications, including trace gas sensing, thermal imaging, and free-space communications. Recently, there has been significant progress in developing a mid-IR photonics platform in Si, which is highly transparent in the mid-IR, due to the ease of fabrication and CMOS compatibility provided by the Si platform. Here, we discuss our group’s recent contributions to the field of silicon-based mid-IR photonics, including photonic crystal cavities in a Si membrane platform and grating-coupled high-quality factor ring resonators in a silicon-on-sapphire (SOS) platform. Since experimental characterization of microphotonic devices is especially challenging at the mid-IR, we also review our mid-IR characterization techniques in some detail. Additionally, pre- and post-processing techniques for improving device performance, such as resist reflow, Piranha clean/HF dip cycling, and annealing are discussed.

Photonic drop splitters based on silicon photonic crystal cascaded self-collimation ring resonators

2014 ◽  
Author(s):  
Yuan-Yuan Lin ◽  
Xi-Yao Chen ◽  
Jun-Zhen Jiang ◽  
Ping Fu ◽  
Biao Chen ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Ring Resonators ◽  
Silicon Photonic

The 1 × 4 Optical Splitters Based on Silicon Photonic Crystal Self-Collimation Ring Resonators

2012 ◽  
Vol 29 (12) ◽  
pp. 124201 ◽  
Author(s):  
Dong-Xia Zhuang ◽  
Xi-Yao Chen ◽  
Jun-Jun Li ◽  
Ze-Xuan Qiang ◽  
Jun-Zhen Jiang ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Ring Resonators ◽  
Silicon Photonic

Silicon photonic wire Bragg grating for on-chip wavelength (de)multiplexing employing ring resonators

2011 ◽  
Author(s):  
P. Muellner ◽  
R. Bruck ◽  
M. Karl ◽  
M. Baus ◽  
T. Wahlbrink ◽  
...  
Keyword(s):  
Ring Resonators ◽  
Bragg Grating ◽  
Silicon Photonic ◽  
On Chip ◽  
Photonic Wire

High quality factor etchless silicon photonic ring resonators

2010 ◽  
Author(s):  
Lian-Wee Luo ◽  
S. Wiederhecker Gustavo ◽  
Jaime Cardenas ◽  
Michal Lipson
Keyword(s):  
Quality Factor ◽  
High Quality Factor ◽  
Ring Resonators ◽  
High Quality ◽  
Silicon Photonic

Subpicometer thermal shifts in silicon photonic micro-ring resonators with sol-gel claddings (Conference Presentation)

2017 ◽  
Author(s):  
Soha Namnabat ◽  
Kyung-Jo Kim ◽  
Adam M. Jones ◽  
Roland Himmelhuber ◽  
Christopher T. DeRose ◽  
...  
Keyword(s):  
Sol Gel ◽  
Ring Resonators ◽  
Silicon Photonic
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