Applications of Modeling in Oral Solid Dosage Form Development and Manufacturing

2016 ◽  
pp. 1-42 ◽  
Author(s):  
Olav Lyngberg ◽  
Lieve Bijnens ◽  
Jeroen Geens ◽  
Alex Marchut ◽  
Steve Mehrman ◽  
...  
Keyword(s):  
Dosage Form ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Form Development

scholarly journals SOLID DOSAGE FORM DEVELOPMENT OF GLIBENCLAMIDE WITH INCREASING THE SOLUBILITY AND DISSOLUTION RATE USING COCRYSTALLIZATION

2018 ◽  
Vol 10 (6) ◽  
pp. 181
Author(s):  
Arif Budiman ◽  
Sandra Megantara ◽  
Putri Raraswati ◽  
Tazyinul Qoriah
Keyword(s):  
Dissolution Rate ◽  
Dosage Form ◽  
Crystallization Process ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Infra Red ◽  
Form Development

Objective: The aim of this study was to develop a solid dosage form of glibenclamide with increasing the solubility properties of glibenclamide with cocrystallization method.Methods: Virtual screening was performed to investigate the interaction between glibenclamide and a co-former. Saccharin, the selected co-former, then co-crystallized with glibenclamide with equimolar ratios of 1:1 and 1:2 using the solvent evaporation method. Further characterization was performed using an infra-red (IR) spectrophotometer, differential scanning calorimetry (DSC), and powder x-ray diffraction (PXRD).Results: Co-crystals of 1:2 equimolar ratio were more highly soluble compared to pure glibenclamide (30-fold for 12 h and 24-fold for 24 h). The dissolution rate had also increased from 46.838% of pure glibenclamide to 77.655% of glibenclamide co-crystal in 60 min. There was no chemical reaction observed during the co-crystallization process based on the IR spectrum. However, there was a new peak in the X-Ray diffractogram and a reduction of melting point in the DSC curve, indicating the formation of co-crystals.Conclusion: The optimal co-crystal ratio of glibenclamide-saccharin was found to be 1:2, which was successful in improving the solubility of glibenclamide.

Benefits of Fractal Approaches in Solid Dosage Form Development

2019 ◽  
Vol 36 (11) ◽  
Author(s):  
Renata Abreu-Villela ◽  
Martin Kuentz ◽  
Isidoro Caraballo
Keyword(s):  
Dosage Form ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Form Development

Significance of Pharmaceutical Excipients on Solid Dosage form Development: A Brief Review

2016 ◽  
Vol 6 (3) ◽  
pp. 191
Author(s):  
Sandesh Narayan Somnache ◽  
Ajeet Madhukar Godbole ◽  
Pankaj Sadashiv Gajare ◽  
Sapna Kashyap
Keyword(s):  
Dosage Form ◽  
Pharmaceutical Excipients ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Form Development

scholarly journals Evaluation of Tropaeolin 000-1 as a Colorimetric Reagent for Assay of Duloxetine and Escitalopram in Solid Dosage Form

2016 ◽  
Vol 15 (3) ◽  
pp. 613
Author(s):  
Mani Ganesh ◽  
Abidov Sh Aziz ◽  
Mei Mei Peng ◽  
Ramaswamy Ravikumar ◽  
Kalaimani Sakthimanigandan ◽  
...  
Keyword(s):  
Dosage Form ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Colorimetric Reagent

Application of pressurized liquid extraction technology to pharmaceutical solid dosage form analysis

2002 ◽  
Vol 968 (1-2) ◽  
pp. 257-261 ◽  
Author(s):  
T.H Hoang ◽  
R Farkas ◽  
C Wells ◽  
S McClintock ◽  
M Di Maso
Keyword(s):  
Dosage Form ◽  
Liquid Extraction ◽  
Pressurized Liquid Extraction ◽  
Extraction Technology ◽  
Form Analysis ◽  
Solid Dosage Form ◽  
Solid Dosage
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