Chromothripsis Detectable in Small Supernumerary Marker Chromosomes (sSMC) Using Fluorescence In Situ Hybridization (FISH)

2018 ◽  
pp. 79-84 ◽  
Author(s):  
Thomas Liehr
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Marker Chromosomes ◽  
Small Supernumerary Marker Chromosomes ◽  
Supernumerary Marker Chromosomes

Cryptorchidism and Marker Chromosomes: Identification of Marker Chromosomes by Fluorescence in situ Hybridization

1995 ◽  
Vol 55 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Isoji Sasagawa ◽  
Teruhiro Nakada ◽  
Manabu Ishigooka ◽  
Masahiko Tomaru ◽  
Toshihiro Sawamura ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Marker Chromosomes

Clinical findings in patients with marker chromosomes identified by fluorescence in situ hybridization

1993 ◽  
Vol 91 (6) ◽  
Author(s):  
Rina Plattner ◽  
NylaA. Heerema ◽  
PatriciaN. Howard-Peebles ◽  
JudithH. Miles ◽  
Shirley Soukup ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Clinical Findings ◽  
Marker Chromosomes

Characterization of unusual marker chromosomes in testicular tumors by fluorescence in situ hybridization

1991 ◽  
Vol 56 (1) ◽  
pp. 97 ◽  
Author(s):  
Aurelia M. Meloni ◽  
Carol Berger ◽  
Robert Dobbs ◽  
Ralph White ◽  
Avery A. Sandberg
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Testicular Tumors ◽  
Marker Chromosomes

Whole Chromosome Painting and Multiplex Fluorescence In Situ Hybridization in Detecting Complex Chromosomal Aberrations in Myelodysplastic Syndromes.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4853-4853
Author(s):  
Jianyong Li ◽  
Bing Xiao ◽  
Lijuan Chen ◽  
Yu Zhu ◽  
Wei Xu ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Chromosomal Aberrations ◽  
Myelodysplastic Syndromes ◽  
Chromosome Painting ◽  
Banding Technique ◽  
Marker Chromosomes ◽  
Molecular Cytogenetic ◽  
Whole Chromosome Painting

Abstract Objective To explore the value of the technique of whole chromosome painting (WCP) and multiplex fluorescence in situ hybridization (M-FISH) in the detection of complex chromosomal aberrations (CCAs) of myelodysplastic syndromes (MDS). Methods M-FISH was used in seven MDS patients with CCAs detected by R-banding technique to refine CCAs, and to identify cryptic translocations and characterization of marker chromosomes. Dual-color WCP procedures were further performed in 7 cases to confirm some rearrangements detected by M-FISH. Results In all cases, M-FISH confirmed all results of R-banding.The composition and origin of 6 kinds of marker chromosomes, 9 kinds of chromosomes with additional material undetermined and 5 kinds of derivative chromosomes undefined by CC were defined after M-FISH analysis; 4 kinds of cryptic translocations overlooked by CC were found on derivative chromosomes and previously normal appearing chromosomes. In addition, M-FISH revealed some nonrandom aberrations: aberrations involving chromosome 17 (5/7) and -5/5q- (4/7) were the two most frequent aberrations. Fluorescence flaring is a main factor leading to misinterpretations. Some misclassified and missed chromosomal aberrations by M-FISH were corrected by WCP. Conclusions M-FISH is a powerful molecular cytogenetic tool in clarification of CCAs. Complementary WCP helped us identify misclassified and missed chromosomal aberrations by M-FISH. CC in combination with molecular cytogenetic techniques M-FISH and WCP can unravel complex chromosomal aberrations more precisely.

scholarly journals Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization

1993 ◽  
Vol 70 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Masafumi Taniwaki ◽  
Michael R. Speicher ◽  
Christoph Lengauer ◽  
Anna Jauch ◽  
Susanne Popp ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Acute Nonlymphocytic Leukemia ◽  
Marker Chromosomes
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