In Vivo Function of GABAA Receptor Subtypes Unraveled With Mutant Mice

2004 ◽  
pp. 95-111
Author(s):  
Jean-Marc Fritschy
Keyword(s):  
Gabaa Receptor ◽  
Mutant Mice ◽  
Receptor Subtypes ◽  
Gabaa Receptor Subtypes

scholarly journals GABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [18F]flumazenil PET

NeuroImage ◽  
2017 ◽  
Vol 150 ◽  
pp. 279-291 ◽  
Author(s):  
Adrienne Müller Herde ◽  
Dietmar Benke ◽  
William T. Ralvenius ◽  
Linjing Mu ◽  
Roger Schibli ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Mouse Brain ◽  
Receptor Occupancy ◽  
Receptor Subtypes ◽  
Regional Mapping ◽  
Gabaa Receptor Subtypes

GABAA-Receptor Subtypes: Pharmacological Significance and Mutational Analysis in Vivo

1996 ◽  
pp. 157-171 ◽  
Author(s):  
H. Mohler ◽  
J. M. Fritschy ◽  
D. Benke ◽  
J. Benson ◽  
U. Rudolph ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Mutational Analysis ◽  
Receptor Subtypes ◽  
Pharmacological Significance ◽  
Gabaa Receptor Subtypes

Differentiating the role of γ-aminobutyric acid type A (GABAA) receptor subtypes

2004 ◽  
Vol 32 (3) ◽  
pp. 553-556 ◽  
Author(s):  
K.A. Wafford ◽  
A.J. Macaulay ◽  
R. Fradley ◽  
G.F. O'Meara ◽  
D.S. Reynolds ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Type A ◽  
Aminobutyric Acid ◽  
Receptor Subtype ◽  
Receptor Subtypes ◽  
Acid Type ◽  
Gabaa Receptor Subtypes ◽  
Subtype Selective

The inhibitory tone maintained throughout the central nervous system relies predominantly on the activity of neuronal GABAA (γ-aminobutyric acid type A) receptors. This receptor family comprises various subtypes that have unique regional distributions, but little is known about the role played by each subtype. The majority of the receptors contain a γ2 subunit and are sensitive to modulation by BZs (benzodiazepines), but differ with regard to α and β subunits. Mutagenesis studies combined with molecular modelling have enabled a greater understanding of receptor structure and dynamics. This can now be extended to in vivo activity through translation to genetically modified mice containing these mutations. Ideally, the mutation should leave normal receptor function intact, and this is the case with mutations affecting the BZ-binding site of the GABAA receptor. We have generated mutations, which affect the BZ site of different α subunits, to enable discrimination of the various behavioural consequences of BZ drug action. This has aided our understanding of the roles played by individual GABAA receptor subtypes in particular behaviours. We have also used this technique to explore the role of different β subunits in conferring the anaesthetic activity of etomidate. This technique together with the development of subtype-selective compounds facilitates our understanding of the roles played by each receptor subtype.

scholarly journals α2 Subunit–Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus

2017 ◽  
Vol 92 (2) ◽  
pp. 101-112 ◽  
Author(s):  
A. Kerstin Lindemeyer ◽  
Yi Shen ◽  
Ferin Yazdani ◽  
Xuesi M. Shao ◽  
Igor Spigelman ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Rat Hippocampus ◽  
Receptor Subtypes ◽  
Functional Plasticity ◽  
Gabaa Receptor Subtypes

Neurosteroids may differentially affect the function of two native GABAA receptor subtypes in the rat brain

1998 ◽  
Vol 357 (4) ◽  
pp. 401-407 ◽  
Author(s):  
Giovanna Schmid ◽  
Roberta Sala ◽  
Giambattista Bonanno ◽  
M. Raiteri
Keyword(s):  
Rat Brain ◽  
Gabaa Receptor ◽  
Receptor Subtypes ◽  
Gabaa Receptor Subtypes

scholarly journals Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Cecilia M. Borghese ◽  
Melissa Herman ◽  
Lawrence D. Snell ◽  
Keri J. Lawrence ◽  
Hyun-Young Lee ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Receptor Subtypes ◽  
Gabaa Receptor Subtypes
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