Transport Mechanisms of Resistance to Drugs and Toxic Metals

2009 ◽  
pp. 111-120
Author(s):  
Adrian R. Walmsley ◽  
Barry P. Rosen

Author(s):  
Jared Grantham ◽  
Larry Welling

In the course of urine formation in mammalian kidneys over 90% of the glomerular filtrate moves from the tubular lumen into the peritubular capillaries by both active and passive transport mechanisms. In all of the morphologically distinct segments of the renal tubule, e.g. proximal tubule, loop of Henle and distal nephron, the tubular absorbate passes through a basement membrane which rests against the basilar surface of the epithelial cells. The basement membrane is in a strategic location to affect the geometry of the tubules and to influence the movement of tubular absorbate into the renal interstitium. In the present studies we have determined directly some of the mechanical and permeability characteristics of tubular basement membranes.



1973 ◽  
Vol 131 (1) ◽  
pp. 109-114 ◽  
Author(s):  
G. M. Green
Keyword(s):  




1998 ◽  
Vol 95 (6) ◽  
pp. 1427-1432 ◽  
Author(s):  
J. P. Travers


Author(s):  
A.W. Smith ◽  
A.D. Gordon


2016 ◽  
Vol 186 (6) ◽  
pp. 640-646
Author(s):  
Alexei V. Samokhvalov ◽  
Alexander S. Mel'nikov ◽  
Alexander I. Buzdin




Author(s):  
Arianna Filippelli ◽  
Valerio Ciccone ◽  
Sandra Donnini ◽  
Lucia Morbidelli


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