NMR Analysis of Native-State Protein Conformational Flexibility by Hydrogen Exchange

2008 ◽  
pp. 285-310 ◽  
Author(s):  
Griselda Hernández ◽  
David M. LeMaster
Keyword(s):  
Hydrogen Exchange ◽  
Conformational Flexibility ◽  
Nmr Analysis ◽  
Native State

Relationship between the Native-State Hydrogen Exchange and Folding Pathways of a Four-Helix Bundle Protein

Biochemistry ◽  
2002 ◽  
Vol 41 (25) ◽  
pp. 7998-8003 ◽  
Author(s):  
Ruiai Chu ◽  
Wuhong Pei ◽  
Jiro Takei ◽  
Yawen Bai
Keyword(s):  
Hydrogen Exchange ◽  
Native State ◽  
Helix Bundle ◽  
Folding Pathways ◽  
Four Helix Bundle ◽  
Bundle Protein

Experimental and theoretical evidences of conformational flexibility of C-glycosides. NMR analysis and molecular mechanics calculations of C-lactose and its O-analogue

1995 ◽  
Vol 36 (35) ◽  
pp. 6329-6332 ◽  
Author(s):  
Juan-Félix Espinosa ◽  
Manuel Martín-Pastor ◽  
Juan L. Asensio ◽  
Hansjörg Dietrich ◽  
Manuel Martín-Lomas ◽  
...  
Keyword(s):  
Molecular Mechanics ◽  
Conformational Flexibility ◽  
Nmr Analysis ◽  
Molecular Mechanics Calculations

scholarly journals Detection of Native-State Nonadditivity in Double Mutant Cycles via Hydrogen Exchange

2010 ◽  
Vol 132 (23) ◽  
pp. 8010-8019 ◽  
Author(s):  
Joshua A. Boyer ◽  
Cristina J. Clay ◽  
K. Scott Luce ◽  
Marshall H. Edgell ◽  
Andrew L. Lee
Keyword(s):  
Double Mutant ◽  
Hydrogen Exchange ◽  
Native State

scholarly journals Protein folding intermediates: native-state hydrogen exchange

Science ◽  
1995 ◽  
Vol 269 (5221) ◽  
pp. 192-197 ◽  
Author(s):  
Y Bai ◽  
T. Sosnick ◽  
L Mayne ◽  
S. Englander
Keyword(s):  
Protein Folding ◽  
Hydrogen Exchange ◽  
Native State ◽  
Folding Intermediates

scholarly journals Microscopic stability of cold shock protein a examined by NMR native state hydrogen exchange as a function of urea and trimethylamine N-oxide

2008 ◽  
Vol 9 (2) ◽  
pp. 290-301 ◽  
Author(s):  
Victor A. Jaravine ◽  
Klara Rathgeb-Szabo ◽  
Andrei T. Alexandrescu
Keyword(s):  
Hydrogen Exchange ◽  
Cold Shock ◽  
Protein A ◽  
Cold Shock Protein ◽  
Native State

Hydrogen exchange and structural dynamics of proteins and nucleic acids

1983 ◽  
Vol 16 (4) ◽  
pp. 521-655 ◽  
Author(s):  
S. Walter Englander ◽  
Neville R. Kallenbach
Keyword(s):  
Free Energy ◽  
Nucleic Acids ◽  
Structural Dynamics ◽  
Hydrogen Exchange ◽  
Native State ◽  
Structural Work

Though the structures presented in crystallographic models of macromolecules appear to possess rock-like solidity, real proteins and nucleic acids are not particularly rigid. Most structural work to date has centred upon the native state of macromolecules, the most probable macromolecular form. But the native state of a molecule is merely its most abundant form, certainly not its only form. Thermodynamics requires that all other possible structural forms, however improbable, must also exist, albeit with representation corresponding to the factor exp( — Gi/RT) for each state of free energy Gi (see Moelwyn-Hughes, 1961), and one appreciates that each molecule within a population of molecules will in time explore the vast ensemble of possible structural states.

scholarly journals Cytochrome c folding pathway: Kinetic native-state hydrogen exchange

2002 ◽  
Vol 99 (19) ◽  
pp. 12173-12178 ◽  
Author(s):  
L. Hoang ◽  
S. Bedard ◽  
M. M. G. Krishna ◽  
Y. Lin ◽  
S. W. Englander
Keyword(s):  
Cytochrome C ◽  
Hydrogen Exchange ◽  
Folding Pathway ◽  
Native State

Microsecond Protein Folding Kinetics from Native-State Hydrogen Exchange†

Biochemistry ◽  
1997 ◽  
Vol 36 (29) ◽  
pp. 8686-8691 ◽  
Author(s):  
Cammon B. Arrington ◽  
Andrew D. Robertson
Keyword(s):  
Protein Folding ◽  
Hydrogen Exchange ◽  
Folding Kinetics ◽  
Native State
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