Insights Into Leydig Cell Function From Mice With Genetically Modified Gonadotropin Action

2007 ◽  
pp. 253-261
Author(s):  
Ilpo Huhtaniemi
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Genetically Modified ◽  
Leydig Cell Function

DISORDERS OF LEYDIG CELL FUNCTION IN PRIMARY ADRENAL INSUFFICIENY

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S61
Author(s):  
R. Mies ◽  
D. Heesen ◽  
W. Winkelmann
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Leydig Cell Function

FSH regulates cultured Leydig cell function via Sertoli cell proteins: An in vitro study

1985 ◽  
Vol 132 (2) ◽  
pp. 729-734 ◽  
Author(s):  
M. Benahmed ◽  
C. Grenot ◽  
E. Tabone ◽  
P. Sanchez ◽  
A.M. Morera
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Function ◽  
In Vitro Study ◽  
Vitro Study ◽  
Leydig Cell Function

Impaired Testicular Function in Patients With Carcinoma-In-Situ of the Testis

1999 ◽  
Vol 17 (1) ◽  
pp. 173-173 ◽  
Author(s):  
Peter Meidahl Petersen ◽  
Aleksander Giwercman ◽  
Steen W. Hansen ◽  
Jørgen G. Berthelsen ◽  
Gedske Daugaard ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Leydig Cell ◽  
Carcinoma In Situ ◽  
Cell Function ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Testicular Dysfunction ◽  
Leydig Cell Function

PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis. PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of 24 patients and no evidence of CIS in the other group of 30 patients. Semen quality and serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were compared in these two groups of men after orchidectomy but before further treatment for testicular cancer. RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P < .001) and generally lower testosterone levels (median, 12.5 nmol/L v 15.5 nmol/L; P = .13) were found in the CIS group. The proportion of patients with Leydig cell dysfunction was higher in the group of patients with CIS (11 of 24) than in the group of patients without (two of 30) (P = .01). Sperm concentration and total sperm count were significantly lower (P < .001) in patients with CIS (median, 0.03 × 106/mL and 0.10 × 106, respectively) than in patients without (median, 9.1 × 106/mL and 32 × 106, respectively), whereas the levels of FSH were significantly higher (P < .001) in the former group of men (median, 19.6 IU/L v 9.0 IU/L). CONCLUSION: Not only spermatogenesis but also Leydig cell function is impaired in testes with CIS. This impairment could be due to common factors in the pathogenesis of germ cell neoplasm and testicular dysfunction. Alternatively, CIS cells may have a negative impact on Leydig cell function.

scholarly journals Leydig Cell Function in Long-term Testosterone-immunized Rats

1983 ◽  
Vol 4 (1) ◽  
pp. 95-103 ◽  
Author(s):  
RICHARD M. SHARPE ◽  
HAMISH M. FRASER
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Leydig Cell Function

Role of Prostaglandins in Leydig-Cell Stimulation by hCG and Leydig-Cell Function

1981 ◽  
pp. 691-711 ◽  
Author(s):  
F. Haour ◽  
J. Mather ◽  
B. Bizzini-Kouznetzova ◽  
F. Dray
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Cell Stimulation ◽  
Leydig Cell Function

New Aspects of Leydig Cell Function

1997 ◽  
pp. 125-138 ◽  
Author(s):  
R. Middendorff ◽  
D. Müller ◽  
H. J. Paust ◽  
A. F. Holstein ◽  
M. S. Davidoff
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Leydig Cell Function

Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function.

2020 ◽  
Vol 105 (6) ◽  
pp. 1868-1877 ◽  
Author(s):  
Jakob Albrethsen ◽  
Trine Holm Johannsen ◽  
Niels Jørgensen ◽  
Hanne Frederiksen ◽  
Henriette P Sennels ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Reference Range ◽  
Serum Insulin ◽  
Peptide Hormone ◽  
Fat Percentage ◽  
Pubertal Stage ◽  
Baseline Serum ◽  
Liquid Chromatography Tandem Mass ◽  
Leydig Cell Function

Abstract Background The peptide hormone insulin-like factor 3 (INSL3) is a marker for Leydig cell function and the clinical use of serum INSL3 measurements has been suggested by several groups. Aim (1) To establish a reference range for liquid chromatography–tandem mass spectrometry (LC-MS/MS) of serum INSL3 in healthy boys and men; and (2) to compare the associations of serum INSL3 and testosterone (T) to pubertal stage, lifestyle factors, diurnal variation, body composition, and human chorionic gonadotropin (hCG) stimulation. Results In a reference range based on LC-MS/MS analysis of serum from 1073 boys and men, INSL3 increased from levels close to the detection limit (0.03 µg/L) in prepubertal boys to a maximum mean level of 1.3 µg/L (95% CI, 0.9-2.7) in young men (19-40 years of age) and decreased slightly in older men (0.1 µg/L per decade). Serum T, but not INSL3, was associated with body mass index or body fat percentage and with alcohol consumption. Smoking was positively associated with serum T, but negatively associated with INSL3. There were significant diurnal variations in both INSL3 and T in men (P &lt; 0.001), but serum INSL3 varied substantially less, compared with serum T (± 11% vs ± 26%). Mean serum INSL3 increased after hCG stimulation, but less than T (+ 17% vs + 53%). In both healthy men and in patients suspected of testicular failure, baseline serum INSL3 was more closely associated to the hCG-induced increase in serum T than baseline T itself. Conclusion Measurement of serum INSL3 by LC-MS/MS has promise as a marker of testicular disorders.

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