Rodent Transgenesis Mediated by a Novel Hyperactive Sleeping Beauty Transposon System

2011 ◽  
pp. 87-99 ◽  
Author(s):  
Lajos Mátés
Keyword(s):  
Sleeping Beauty ◽  
Sleeping Beauty Transposon

Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System Reduces Neovascularisation in Rats

2019 ◽  
Author(s):  
Maria Hernandez ◽  
Sergio Recalde ◽  
Laura Garcia-Garcia ◽  
Jaione Bezunartea ◽  
Csaba Miskey ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Sleeping Beauty ◽  
Sleeping Beauty Transposon

Sleeping Beauty transposon mutagenesis identifies genes driving the initiation and metastasis of uterine leiomyosarcoma

2021 ◽  
pp. canres.0356.2021
Author(s):  
Michiko Kodama ◽  
Hiroko Shimura ◽  
Jean C Tien ◽  
Justin Y Newberg ◽  
Takahiro Kodama ◽  
...  
Keyword(s):  
Sleeping Beauty ◽  
Transposon Mutagenesis ◽  
Uterine Leiomyosarcoma ◽  
Sleeping Beauty Transposon

scholarly journals Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery

2017 ◽  
Vol 9 ◽  
pp. 1-11 ◽  
Author(s):  
Laura Garcia-Garcia ◽  
Sergio Recalde ◽  
Maria Hernandez ◽  
Jaione Bezunartea ◽  
Juan Roberto Rodriguez-Madoz ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Epithelial Cells ◽  
Sleeping Beauty ◽  
Sleeping Beauty Transposon ◽  
Rat Iris

scholarly journals Restoration of dystrophin expression using the Sleeping Beauty transposon

PLoS Currents ◽  
2011 ◽  
Vol 3 ◽  
pp. RRN1296 ◽  
Author(s):  
Sofia Muses ◽  
Jennifer E Morgan ◽  
Dominic J. Wells
Keyword(s):  
Sleeping Beauty ◽  
Sleeping Beauty Transposon ◽  
Dystrophin Expression

scholarly journals Potential limitations of the Sleeping Beauty transposon use in gene expression studies

2019 ◽  
Author(s):  
Weronika Sowińska ◽  
Mateusz Wawro ◽  
Aleksandra Solecka ◽  
Aneta Kasza
Keyword(s):  
Transcript Level ◽  
Sleeping Beauty ◽  
Full Spectrum ◽  
Cellular Targets ◽  
Sleeping Beauty Transposon ◽  
Transgenic Cell ◽  
Expression Studies ◽  
Rapid Generation ◽  
Gene Expression Studies ◽  
Transgenic Cell Line

MCPIP2 is the least known member of the MCPIP family of proteins. Recently we have found that it is a new RNase involved in transcript turnover. However, the full spectrum of its cellular targets is still unidentified. To discover transcripts which are regulated by this protein we have employed Sleeping Beauty transposons. This tool allows for rapid generation of a stable transgenic cell line with inducible expression of the desired gene. In this study, we analysed how the Sleeping Beauty system itself influences expression of chosen genes, namely IL-6, Regnase-1 and VEGF. We found that the system alone may influence expression of IL-6. Our results indicate that Sleeping Beauty transposons should be used with caution in studies that are focused on changes in the transcript level.

scholarly journals Generation of CYP4A1 transgenic rats using the Sleeping Beauty transposon system

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Fan Fan ◽  
Howard Jacob ◽  
Aron Geurts ◽  
Sydney Murphy ◽  
Richard J. Roman
Keyword(s):  
Sleeping Beauty ◽  
Transgenic Rats ◽  
Sleeping Beauty Transposon
Sign in / Sign up

Export Citation Format

Share Document