Use of Unnatural Amino Acids to Probe Structure–Activity Relationships and Mode-of-Action of Antimicrobial Peptides

2011 ◽  
pp. 169-183 ◽  
Author(s):  
Alessandro Tossi ◽  
Marco Scocchi ◽  
Sotir Zahariev ◽  
Renato Gennaro
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Mode Of Action ◽  
Unnatural Amino Acids ◽  
Structure Activity Relationships ◽  
Structure Activity

Elucidation of the Structure-Activity Relationships of Apelin: Influence of Unnatural Amino Acids on Binding, Signaling, and Plasma Stability

ChemMedChem ◽  
2011 ◽  
Vol 7 (2) ◽  
pp. 318-325 ◽  
Author(s):  
Alexandre Murza ◽  
Alexandre Parent ◽  
Elie Besserer-Offroy ◽  
Hugo Tremblay ◽  
Félix Karadereye ◽  
...  
Keyword(s):  
Amino Acids ◽  
Unnatural Amino Acids ◽  
Plasma Stability ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Antiprotozoal structure‐activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action

2021 ◽  
Author(s):  
Michael Brand ◽  
Lei Wang ◽  
Stefano Agnello ◽  
Silvia Gazzola ◽  
Flavio M. Gall ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2453-2461
Author(s):  
Min-Che Tung ◽  
Keng-Chang Tsai ◽  
Kit-Man Fung ◽  
Ming-Jaw Don ◽  
Tien-Sheng Tseng
Keyword(s):  
Natural Products ◽  
Protein Kinase ◽  
Tyrosine Kinase ◽  
Mode Of Action ◽  
Drug Target ◽  
Receptor Protein ◽  
Inflammatory Disorder ◽  
Spleen Tyrosine Kinase ◽  
Structure Activity Relationships ◽  
Structure Activity

The cytosolic non-receptor protein kinase, spleen tyrosine kinase (SYK), is an attractive drug target in autoimmune, inflammatory disorder, and cancers indications.

Perspective on FTY720, an Immunosuppressant

Synthesis ◽  
2018 ◽  
Vol 50 (05) ◽  
pp. 968-983 ◽  
Author(s):  
Sivaraman Balasubramaniam ◽  
Ganapathy Sankaran ◽  
Sneh Badle
Keyword(s):  
Chemical Modification ◽  
Mode Of Action ◽  
Immunosuppressive Drugs ◽  
Binding Studies ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Fingolimod Hydrochloride

FTY720 {fingolimod hydrochloride, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride}, a novel immunosuppressant, was discovered by chemical modification based on the structure activity relationships of ISP-I (myriocin), a metabolite of the fungus Isaria­ sinclairii. This short perspective provides insights to the various strategies available in the literature for the synthesis of FTY720 and its analogues.1 Introduction2 Classification of Immunosuppressive Drugs3 The Rise of FTY7204 Different Synthetic Strategies for FTY7205 Analogues of FTY7206 Binding Studies of FTY7207 Mode of Action8 Conclusion

Antimicrobial Peptides and Their Superior Fluorinated Analogues: Structure-Activity Relationships as Revealed by NMR Spectroscopy and MD Calculations

ChemBioChem ◽  
2010 ◽  
Vol 11 (17) ◽  
pp. 2424-2432 ◽  
Author(s):  
M. Dolores Díaz ◽  
Martina Palomino-Schätzlein ◽  
Francisco Corzana ◽  
Cecilia Andreu ◽  
Rodrigo J. Carbajo ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Antimicrobial Peptides ◽  
Structure Activity Relationships ◽  
Structure Activity
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