Carbon–Carbon Bond-Forming Enzymes for the Synthesis of Non-natural Amino Acids

2011 ◽  
pp. 73-85
Author(s):  
Pere Clapés ◽  
Jesús Joglar ◽  
Mariana Gutiérrez
Keyword(s):  
Amino Acids ◽  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Carbon Bond ◽  
Natural Amino Acids

ChemInform Abstract: Enantioselective Synthesis of α-Amino Acids via Carbon-Carbon Bond Forming Radical Reactions.

ChemInform ◽  
2010 ◽  
Vol 22 (49) ◽  
pp. no-no
Author(s):  
D. P. G. HAMON ◽  
R. A. MASSY-WESTROPP ◽  
P. RAZZINO
Keyword(s):  
Amino Acids ◽  
Enantioselective Synthesis ◽  
Radical Reactions ◽  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Carbon Bond

scholarly journals Front Cover: Reductive Carbon–Carbon Bond Forming Reactions with Carbonyls Mediated by Rh–H Complexes (Eur. J. Org. Chem. 42/2020)

2020 ◽  
Vol 2020 (42) ◽  
pp. 6501-6501
Author(s):  
Kazuyuki Sato ◽  
Motoyuki Isoda ◽  
Atsushi Tarui ◽  
Masaaki Omote
Keyword(s):  
Carbon Bond ◽  
Front Cover ◽  
Bond Forming ◽  
Carbon Carbon Bond ◽  
Bond Forming Reactions

Nickel-Catalyzed Electronically-Reversed Enantioselective Hydrocarbofunctionalizations of Acrylamides

Synlett ◽  
2021 ◽  
Author(s):  
Lou Shi ◽  
Wei Shu
Keyword(s):  
Nickel Catalyst ◽  
Functional Group ◽  
Optically Active ◽  
Forming Process ◽  
Carbon Bond ◽  
Bond Forming ◽  
Synthetic Strategy ◽  
Carbon Carbon Bond ◽  
Wide Range ◽  
Simple Protocol

Asymmetric hydrocarbofunctionalizations of alkenes has emerged as an efficient synthetic strategy for accessing optically active molecules via carbon-carbon bond-forming process from readily available alkenes and carbo-electrophiles. Herein, we present a summary of the efforts from our group to control the regio- and enantioselectivity of hydrocarbofunctionalizations of electron-deficient alkenes with a nickel catalyst and chiral bisoxazolidine ligand. The reaction undergoes electron-reversed hydrocarbofunctionalizations acrylamides with excellent enantioselectivity. This operationally simple protocol enables the asymmetric hydroalkylation, hydrobenzylation and hydropropargylation of acrylamides. This reaction is useful for preparing a wide range of α-branched chiral amides with broad functional group tolerance.

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