Dicarbonyl compounds in the synthesis of heterocycles under green conditions

Carbon–carbon and carbon-heteroatom bond forming reactions are strategically employed for the generation of a variety of heterocyclic systems. This class of compounds represents the most general structural unit, present in many natural compounds. They are recognized for their valuable biologically properties and wide range of applications in medicinal, pharmaceutical, and other related fields of chemistry. This is an updated review on the use of dicarbonyl compounds under environmentally friendly conditions to access a series of heterocyclic structures, e.g., quinoxaline, quinazolinones, benzochalcogenazoles, indoles, among others. Synthetic protocols involving copper-catalyzed, multicomponent and cascade reactions, decarboxylative cyclization, recycling of CO2, and electrochemical approaches are presented and discussed.

The Application of C-H bond Functionalization in Total Syntheses of Indole Natural Products

The direct functionalization of unactivated C–H bonds is a rapidly growing field in organic chemistry in recent years because of its indisputable advantages in bond forming reactions in terms of...

Development of Chiral Potassium Strong Brønsted Base Catalysts for Enantioselective Carbon–Carbon Bond-Forming Reactions

Chiral alkaline metal Brønsted bases are traditional and reliable promoters in enantioselective catalysis. Here, new chiral potassium strong base catalysts were developed for enantioselective carbon–carbon bond-forming reactions of weakly acidic...