Stem Cell Therapies for the Treatment of Spinal Cord Injuries: Current Progress in Basic Science and Clinical Research

2013 ◽  
pp. 319-346
Author(s):  
Hilary North ◽  
John Kessler
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Clinical Research ◽  
Basic Science ◽  
Spinal Cord Injuries ◽  
Stem Cell Therapies ◽  
Cell Therapies

scholarly journals Stem cell therapies for acute spinal cord injury in humans: a review

2019 ◽  
Vol 46 (3) ◽  
pp. E10 ◽  
Author(s):  
Michael C. Jin ◽  
Zachary A. Medress ◽  
Tej D. Azad ◽  
Vanessa M. Doulames ◽  
Anand Veeravagu
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Recent Advances ◽  
Cord Injury

Recent advances in stem cell biology present significant opportunities to advance clinical applications of stem cell–based therapies for spinal cord injury (SCI). In this review, the authors critically analyze the basic science and translational evidence that supports the use of various stem cell sources, including induced pluripotent stem cells, oligodendrocyte precursor cells, and mesenchymal stem cells. They subsequently explore recent advances in stem cell biology and discuss ongoing clinical translation efforts, including combinatorial strategies utilizing scaffolds, biogels, and growth factors to augment stem cell survival, function, and engraftment. Finally, the authors discuss the evolution of stem cell therapies for SCI by providing an overview of completed (n = 18) and ongoing (n = 9) clinical trials.

scholarly journals Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Syoichi Tashiro ◽  
Osahiko Tsuji ◽  
Munehisa Shinozaki ◽  
Takahiro Shibata ◽  
Takashi Yoshida ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Functional Recovery ◽  
Synergistic Effects ◽  
Regenerative Therapy ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Functional Training ◽  
Cord Injury

AbstractStem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this review article, we summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of SCI. Although conventional rehabilitative methods have commonly been implemented alone, especially in studies of acute-to-subacute SCI, the combinatorial effects of intensive and advanced methods, including various neurorehabilitative approaches, have also been reported. Separating the concept of combined rehabilitation from regenerative rehabilitation, we suggest that the main roles of regenerative rehabilitation can be categorized as conditioning/reconditioning, functional training, and physical exercise, all of which are indispensable for enhancing functional recovery achieved using stem cell therapies.

scholarly journals Stem cell therapies for injured spinal cord

Ensho Saisei ◽  
2006 ◽  
Vol 26 (1) ◽  
pp. 18-28 ◽  
Author(s):  
Hideyuki Okano ◽  
Masaya Nakamura ◽  
Yoshiaki Toyama
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Injured Spinal Cord ◽  
Stem Cell Therapies ◽  
Cell Therapies

scholarly journals Stem Cell Therapies for Cervical Spinal Cord Injury

10.5772/63580 ◽  
2016 ◽  
Author(s):  
Vanessa M. Doulames ◽  
Laura M. Marquardt ◽  
Bhavaani Jayaram ◽  
Christine D. Plant ◽  
Giles W. Plant
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Cord Injury

scholarly journals Stem cell therapies for spinal cord injury

2010 ◽  
Vol 6 (7) ◽  
pp. 363-372 ◽  
Author(s):  
Vibhu Sahni ◽  
John A. Kessler
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Cord Injury

Sternal bone marrow is a suitable autologous cell source for cardiac stem cell therapies

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
M. Arar ◽  
A. Rotärmel ◽  
A.-K. Knoefel ◽  
H. Baraki ◽  
I. Kutschka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cardiac Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Autologous Cell ◽  
Cell Source
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