Sociocultural History of Epilepsy

2010 ◽  
pp. 35-43 ◽  
Author(s):  
Peter Wolf
PEDIATRICS ◽  
1991 ◽  
Vol 88 (6) ◽  
pp. 1219-1225 ◽  
Author(s):  
Roberto F. Tuchman ◽  
Isabelle Rapin ◽  
Shlomo Shinnar

In a previously described population of 314 autistic and 237 dysphasic nonautistic children, after exclusion of 12 autistic girls with Rett syndrome, 14% (42 of 302) of autistic children and 8% (19 of 237) of dysphasic children had epilepsy (P = .03). The major risk factors for epilepsy were severe mental deficiency and the combination of severe mental deficiency with a motor deficit. In autistic children without severe mental deficiency, motor deficit, associated perinatal or medical disorder, or a positive family history of epilepsy, epilepsy occurred in 6% (10 of 160) which was analogous to the 8% (14 of 168) found in similar dysphasic nonautistic children. The language subtype of verbal auditory agnosia is associated with the highest risk of epilepsy in autistic (41%, 7 of 17) and dysphasic (58%, 7 of 12) children. The higher percentage of epilepsy in autistic girls, 24% (18 of 74) compared with boys 11% (25 of 228) (P = .003), is attributed to the increased prevalence of cognitive and motor deficit in girls. Once the risk attributable to associated cognitive and motor disabilities is taken into account, there is no difference in the risk of epilepsy between autistic and nonautistic dysphasic children.


Author(s):  
Harrison M. Trice ◽  
William J. Staudenmeier

2018 ◽  
Vol 25 (4) ◽  
pp. 618-621 ◽  
Author(s):  
Emilie Panicucci ◽  
Mikael Cohen ◽  
Veronique Bourg ◽  
Fanny Rocher ◽  
Pierre Thomas ◽  
...  

Background: Dalfampridine extended release (DAL) is a broad-spectrum voltage-gated potassium channel blocker that is indicated in multiple sclerosis to improve the nerve conduction of demyelinated axons. Seizures are a known side effect of DAL, which is contraindicated in patients with a history of epilepsy. Objective: Three cases of multiple sclerosis (MS) with de novo convulsive status epilepticus (CSE) probably related to dalfampridine administration are described. Methods: No patients had a history of seizures or renal impairment. Biological tests were normal. A brain magnetic resonance imaging (MRI) showed diffuse cortical and subcortical atrophy without active inflammatory lesions. Results: All three patients presented with CSE that was attributed to DAL and so was discontinued. Conclusion: These case reports illustrate that, aside from seizures, de novo CSE is a potential complication of MS patients treated with DAL.


2020 ◽  
Vol 3 (1) ◽  

Ewing sarcoma is a malignant bone tumor that mainly affects children, adolescents and young adults with more than 1.5 cases per million worldwide. Approximately 20-25% of patients present metastatic disease at the diagnosis, that is often resistant to intensive therapy.We present the case of a 19-year-old male with history of epilepsy who started his condition with weight loss, increased volume, pain, swelling after receiving surgical treatment due to a left distal femur fracture, showing tomographic evidence of a 50-cm tumor with multiple lung lesions, so disarticulation was performed with the Boyd technique, obtaining histopathological result of Ewing’s Sarcoma, and was subsequently sent to the medical oncology service for follow-up and adjuvant treatment with significant clinical and radiological improvement in pulmonary metastatic activity.


Author(s):  
Paulo Cruz Terra ◽  
Marcelo de Souza Magalhães

The city of Rio de Janeiro underwent profound changes between 1870 and the early 20th century. Its population grew dramatically, attracting migrants not only from abroad but also from other regions of Brazil. It also expanded significantly in size, as the construction of trolley and railway lines and the introduction of real estate capital powered the occupation of new areas. Meanwhile, urban reforms aimed at modernization transformed the social ways in which urban space was used. During this period, Rio de Janeiro went from being the capital of the Brazilian Empire to being the capital of the Brazilian Republic. It nevertheless maintained its position as the cultural, political-administrative, commercial, and financial center of the country. Against this backdrop of change, the city was an important arena for the political struggles that marked the period, including demonstrations in favor of abolition and the republic. Rio de Janeiro’s citizens were not inert during this period of transformation, and they found various ways to take action and fight for what they understood to be their rights. Protests, demands, petitions, and a vibrant life organized around social and political associations are examples of the broad repertoire used by the city’s inhabitants to gain a voice in municipal affairs. Citizens’ use of public demands and petitions as a channel to communicate with the authorities, and especially with city officials, shows that while they did not necessarily shun formal politics, they understood politics to be a sphere for dialogue and dispute. The sociocultural history of Rio de Janeiro during this period was therefore built precisely through confrontations and negotiations in which the common people played an active role.


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