Cardiac Mitochondrial Dysfunction in Aging and in Ischemia/Reperfusion Role of Oxygen Free radicals and Cardiolipin

2002 ◽  
pp. 59-69
Author(s):  
G. Paradies ◽  
G. Petrosillo ◽  
F. M. Ruggiero
Keyword(s):  
Free Radicals ◽  
Mitochondrial Dysfunction ◽  
Oxygen Free Radicals ◽  
Ischemia Reperfusion

Efficacy and Mechanisms of Dopexamine in the Prevention of Ischemia-Reperfusion Induced Organ Damage: Role of Oxygen Free Radicals

1997 ◽  
Vol 19 (1-2) ◽  
pp. 181-190 ◽  
Author(s):  
Severina M. Jacinto ◽  
Madhu S. Chintala ◽  
Mustafa F. Lokhandwala ◽  
Bhagavan S. Jandhyala
Keyword(s):  
Free Radicals ◽  
Oxygen Free Radicals ◽  
Ischemia Reperfusion ◽  
Organ Damage

Role of Free Radicals and Lipid Peroxidation in Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

1989 ◽  
Vol 24 (sup162) ◽  
pp. 55-58 ◽  
Author(s):  
S. Ueda ◽  
T. Yoshikawa ◽  
S. Takahashi ◽  
H. Ichikawa ◽  
M. Yasuda ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Ischemia Reperfusion ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury

Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals and biological consequences of scission

1992 ◽  
Vol 111 (1-2) ◽  
Author(s):  
Arshad Rahman ◽  
Fabeha Fazal ◽  
Julie Greensill ◽  
K. Ainley ◽  
J.H. Parish ◽  
...  
Keyword(s):  
Free Radicals ◽  
Oxygen Free Radicals ◽  
Strand Scission ◽  
Dietary Flavonoids

Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs

1986 ◽  
Vol 250 (3) ◽  
pp. H372-H377 ◽  
Author(s):  
G. J. Gross ◽  
N. E. Farber ◽  
H. F. Hardman ◽  
D. C. Warltier
Keyword(s):  
Blood Flow ◽  
Superoxide Dismutase ◽  
Free Radicals ◽  
Oxygen Free Radicals ◽  
Ischemia Reperfusion ◽  
Free Radical Scavengers ◽  
Stunned Myocardium ◽  
Regional Myocardial Blood Flow ◽  
Control Group ◽  
Myocardial Segment

Recent evidence suggests that oxygen free radicals may partially mediate irreversible ischemia-reperfusion injury in the myocardium. In the present study, the effect of a combination of two oxygen free radical scavengers, superoxide dismutase plus catalase (SOD + CAT), on the recovery of subendocardial segment function following 15 min of coronary artery occlusion followed by 3 h of reperfusion ("stunned" myocardium) was compared with a control group in barbital-anesthetized dogs. Myocardial segment shortening (%SS) in the subendocardium of nonischemic and ischemic areas was measured by sonomicrometry and regional blood flow by radioactive microspheres. SOD and CAT were infused into the left atrium 30 min before and throughout the occlusion period. Compared with the control group, %SS in the subendocardium of the ischemic region was significantly (P less than 0.05) greater in the SOD plus CAT-treated group during occlusion and throughout reperfusion. Since there were no significant differences in hemodynamics or regional myocardial blood flow between the SOD plus CAT and the control groups, these results suggest that toxic oxygen free radicals may be partially involved in the reversible ischemic injury that occurs during short periods of coronary occlusion followed by reperfusion.

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