Cortical Cataract

2021 ◽  
pp. 1191-1191
Keyword(s):  
Cortical Cataract

Wavefront analysis in eyes with nuclear or cortical cataract

2002 ◽  
Vol 134 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Teruhito Kuroda ◽  
Takashi Fujikado ◽  
Naoyuki Maeda ◽  
Tetsuro Oshika ◽  
Youko Hirohara ◽  
...  
Keyword(s):  
Wavefront Analysis ◽  
Cortical Cataract

scholarly journals Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xinyue Shen ◽  
Manhui Zhu ◽  
Lihua Kang ◽  
Yuanyuan Tu ◽  
Lele Li ◽  
...  
Keyword(s):  
Culture System ◽  
Lens Opacity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Posterior Subcapsular Cataract ◽  
Cortical Cataract ◽  
Lens Transparency ◽  
Age Related ◽  
Lanosterol Synthase ◽  
Cataract Development

Purpose. Lanosterol synthase (LSS) abnormity contributes to lens opacity in rats, mice, dogs, and human congenital cataract development. This study examined whether LSS pathway has a role in different subtypes of age-related cataract (ARC). Methods. A total of 390 patients with ARC and 88 age-matched non-ARC patients were enrolled in this study. LSS expression was analyzed by western blot and enzyme-linked immunosorbent assay (ELISA). To further examine the function of LSS, we used U18666A, an LSS inhibitor in rat lens culture system. Results. In lens epithelial cells (LECs), LSS expression in LECs increased with opaque degree C II, while it decreased with opaque degree C IV and C V. While in the cortex of age-related cortical cataract (ARCC), LSS expression was negatively related to opaque degree, while lanosterol level was positively correlated to opaque degree. No obvious change in both LSS and lanosterol level was found in either LECs or the cortex of age-related nuclear cataract (ARNC) and age-related posterior subcapsular cataract (ARPSC). In vitro, inhibiting LSS activity induced rat lens opacity and lanosterol effectively delayed the occurrence of lens opacity. Conclusions. This study indicated that LSS and lanosterol were localized in the lens of human ARC, including ARCC, ARNC, and ARPSC. LSS and lanosterol level are only correlated with opaque degree of ARCC. Furthermore, activated LSS pathway in lens is protective for lens transparency in cortical cataract.

Cortical cataract formation prevented by vitamin E and glutathione

1979 ◽  
Vol 29 (6) ◽  
pp. 689-693 ◽  
Author(s):  
M.O. Creighton ◽  
J.R. Trevithick
Keyword(s):  
Vitamin E ◽  
Cataract Formation ◽  
Cortical Cataract

Automatic opacity detection in retro-illumination images for cortical cataract diagnosis

2008 ◽  
Author(s):  
Huiqi Li ◽  
Liling Ko ◽  
Joo Hwee Lim ◽  
Jiang Liu ◽  
Damon Wing Kee Wong ◽  
...  
Keyword(s):  
Cortical Cataract

Lens Epithelial Apoptosis and Cell Proliferation in Human Age-Related Cortical Cataract

2005 ◽  
Vol 15 (2) ◽  
pp. 213-220 ◽  
Author(s):  
A. Charakidas ◽  
A. Kalogeraki ◽  
M. Tsilimbaris ◽  
P. Koukoulomatis ◽  
D. Brouzas ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cataract Extraction ◽  
Fiber Formation ◽  
Small Scale ◽  
Specific Cell ◽  
Extracapsular Cataract Extraction ◽  
Cortical Cataract ◽  
Age Related ◽  
Anterior Lens Capsule ◽  
Human Lenses

Purpose To probe the presence of apoptosis in the epithelium of human lenses with age-related cortical cataract as well as to assess cell proliferation, a predicted consequence of apoptotic cell death, in this specific cell population. Methods DNA fragmentation was assessed using terminal digoxigenin-labeled dUTP nick end labeling (TUNEL) in capsulotomy specimens obtained from patients who underwent either extracapsular cataract extraction for the removal of adult-onset cortical cataract (n=27) or clear lens extraction for the correction of high myopia (n=25). Cell proliferation was assayed in 23 epithelia of cataractous lenses, and 20 epithelia of non-cataractous lenses with the proliferation marker MIB1, a monoclonal antibody against the nuclear antigen Ki-67 that is detected throughout the cell cycle but is absent in the resting (G0) cell. Results TUNEL staining was observed in 25 (92.6%) specimens of cataractous lenses, whereas cells undergoing apoptosis were identified in 2 (8%) of the epithelia from non-catarac-tous lenses. Only two MIB1-positive samples were detected, one of which was a capsule obtained during intracapsular cataract extraction. Conclusions The epithelium of human lenses with cortical cataract undergoes low rate apoptotic death. This limited epithelial apoptosis is unlikely to result in any significant cell density decrease since epithelial gaps are likely to be replaced by cell proliferation at the germinative zone of the anterior lens capsule. Nevertheless, the accumulation of small-scale epithelial losses during lifetime may induce alterations in lens fiber formation and homeostasis and result in loss of lens transparency.

Systemic medications and cortical cataract: the Singapore Epidemiology of Eye Diseases Study

2019 ◽  
Vol 104 (3) ◽  
pp. 330-335 ◽  
Author(s):  
Wei Dai ◽  
Yih Chung Tham ◽  
Miao Li Chee ◽  
Shivani Majithia ◽  
Stanley Poh ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Ace Inhibitors ◽  
Smoking Status ◽  
Medication Use ◽  
Asian Population ◽  
Eye Diseases ◽  
Cortical Cataract ◽  
Glucosidase Inhibitors ◽  
The Mean ◽  
Alpha Glucosidase

Background/aimsTo evaluate the association between systemic medications and cortical cataract prevalence in an Asian population.MethodsThe Singapore Epidemiology of Eye Diseases Study recruited 10 033 Chinese, Malay and Indian residents aged 40+ years living in Singapore. Information on medication use was collected at interview using questionnaires. The presence and severity of cortical cataract were assessed from lens photographs using the modified Wisconsin Cataract Grading System. Associations between medications and the presence of cortical cataract were assessed using logistic regression. Associations between medications and greater severity of cortical cataract (none, minimal, early and late) were assessed using ordinal logistic regression.ResultsA total of 8965 participants were included, the mean age was 57.6 (SD=9.8) years, and 4555 (50.8%) were women. After adjusting for age, gender, ethnicity, body mass index, smoking status, socioeconomic status, hypertension, hyperlipidaemia, diabetes, duration of diabetes and cardiovascular disease, ACE inhibitors (OR=1.27; 95% CI 1.05 to 1.55), fibrates (OR=1.57; 95% CI 1.05 to 2.35), alpha-glucosidase inhibitors (AGIs) (OR=1.85; 95% CI 1.13 to 3.02) and insulin (OR=1.80; 95% CI 1.11 to 2.93) were significantly associated with the presence of cortical cataract. Further adjusting for concurrent medication use did not alter these associations. Consistently, the four medications were also associated with a greater severity level of cortical cataract.ConclusionACE inhibitors, fibrates and AGIs were associated with increased prevalence of cortical cataract in this Asian population, independent of the presence of hypertension, hyperlipidaemia and diabetes, respectively. Whether they contribute to the risk of cortical cataract needs confirmation in longitudinal studies.

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