Cell-Free Hemoglobin: A New Therapeutic Target in Sepsis?

2020 ◽  
pp. 281-292
Author(s):  
L. B. Ware
Keyword(s):  
Therapeutic Target ◽  
Free Hemoglobin ◽  
Hemoglobin A

Plasma Free Hemoglobin: A Novel Diagnostic Test for Assessment of the Depth of Burn Injury

2006 ◽  
Vol 117 (4) ◽  
pp. 1206-1213 ◽  
Author(s):  
Chin-Ho Wong ◽  
Colin Song ◽  
Kien-Seng Heng ◽  
Irene H.C. Kee ◽  
Sim-Leng Tien ◽  
...  
Keyword(s):  
Diagnostic Test ◽  
Burn Injury ◽  
Free Hemoglobin ◽  
Hemoglobin A

STROMA-FREE HEMOGLOBIN — A MYOCARDIAL DEPRESSANT?

1983 ◽  
Vol 23 (7) ◽  
pp. 647
Author(s):  
Lorrie A. Langdale ◽  
Steven A. Gould ◽  
Lakshman R. Sehgal ◽  
Arthur L. Rosen ◽  
Lawrence Krause ◽  
...  
Keyword(s):  
Free Hemoglobin ◽  
Hemoglobin A

Can the Roche hemolysis index be used for automated determination of cell-free hemoglobin? A comparison to photometric assays

2013 ◽  
Vol 46 (13-14) ◽  
pp. 1298-1301 ◽  
Author(s):  
Darinka Todorova Petrova ◽  
Gabriela Ariadna Cocisiu ◽  
Christoph Eberle ◽  
Karl-Heinz Rhode ◽  
Gunnar Brandhorst ◽  
...  
Keyword(s):  
Free Hemoglobin ◽  
Hemoglobin A ◽  
Automated Determination

scholarly journals Free hemoglobin: a boost to platelet thrombi

Blood ◽  
2015 ◽  
Vol 126 (20) ◽  
pp. 2262-2263 ◽  
Author(s):  
Marc Jacquemin ◽  
Kathelijne Peerlinck
Keyword(s):  
Free Hemoglobin ◽  
Hemoglobin A ◽  
Platelet Thrombi

scholarly journals Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target

2017 ◽  
Vol 14 (Supplement_3) ◽  
pp. S251-S252 ◽  
Author(s):  
Ciara M. Shaver ◽  
Nancy Wickersham ◽  
J. Brennan McNeil ◽  
Hiromasa Nagata ◽  
Gillian Sills ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Therapeutic Target ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Free Hemoglobin

Free Hemoglobin: A Dangerous Signal for the Immune System in Patients with Carotid Atherosclerosis?

2007 ◽  
Vol 1107 (1) ◽  
pp. 42-50 ◽  
Author(s):  
B. BUTTARI ◽  
E. PROFUMO ◽  
L. PETRONE ◽  
D. PIETRAFORTE ◽  
A. SIRACUSANO ◽  
...  
Keyword(s):  
Immune System ◽  
Carotid Atherosclerosis ◽  
Free Hemoglobin ◽  
Hemoglobin A

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

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