Splenic Flexure

2020 ◽  
pp. 49-63
Author(s):  
Kevin R. Kniery ◽  
Michael J. Mulcahy ◽  
Scott R. Steele
Keyword(s):  
Swiss Surgery ◽  
2003 ◽  
Vol 9 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Gervaz ◽  
Bühler ◽  
Scheiwiller ◽  
Morel

The central hypothesis explored in this paper is that colorectal cancer (CRC) is a heterogeneous disease. The initial clue to this heterogeneity was provided by genetic findings; however, embryological and physiological data had previously been gathered, showing that proximal (in relation to the splenic flexure) and distal parts of the colon represent distinct entities. Molecular biologists have identified two distinct pathways, microsatellite instability (MSI) and chromosomal instability (CIN), which are involved in CRC progression. In summary, there may be not one, but two colons and two types of colorectal carcinogenesis, with distinct clinical outcome. The implications for the clinicians are two-folds; 1) tumors originating from the proximal colon have a better prognosis due to a high percentage of MSI-positive lesions; and 2) location of the neoplasm in reference to the splenic flexure should be documented before group stratification in future trials of adjuvant chemotherapy in patients with stage II and III colon cancer.


2019 ◽  
Vol 74 (2) ◽  
Author(s):  
Rossella Reddavid ◽  
Laura Esposito ◽  
Andrea Evangelista ◽  
Silvia Sofia ◽  
Maurizio Degiuli

2021 ◽  
Author(s):  
Isaac Cheruiyot ◽  
Roberto Cirocchi ◽  
Jeremiah Munguti ◽  
Justin Davies ◽  
Justus Randolph ◽  
...  

Author(s):  
Amirsina Sharifi ◽  
Seyed Mohsen Ahmadi Tafti ◽  
Mohammadreza Keramati ◽  
Alireza Kazemeini ◽  
Behnam Behboudi

2019 ◽  
Vol 23 (7) ◽  
pp. 693-694 ◽  
Author(s):  
A. Ogura ◽  
R. Kobayashi ◽  
T. Aritake ◽  
T. Maeda ◽  
K. Kawai ◽  
...  

1996 ◽  
Vol 37 (1P1) ◽  
pp. 255-258 ◽  
Author(s):  
D. Makanjuola ◽  
S. Al-Smayer ◽  
I. Al-Orainy ◽  
M. Al-Saleh

Purpose: Our aim was to describe the radiographic features of lobar agenesis of the liver. Material and Methods: Six patients with lobar agenesis of the liver, 5 right- and one left-sided, are presented. CT was used to confirm diagnosis. Chest radiography, barium meals, and urograms were also analyzed. Results: In right-sided agenesis, the following were observed: a) hammock or U-shaped deformity of the stomach; b) colonic interposition of the diaphragm (Chilaiditi's syndrome); and c) reversal of the cranial orientation of the colonic hepatic flexure compared to the splenic flexure. The right kidney was higher in position than the left in both right- and left-sided lobar agenesis. Conclusion: Our radiographic findings can provide a multidisciplinary approach in the identification of this anatomic anomaly.


2017 ◽  
Vol 21 (1) ◽  
pp. 53-57 ◽  
Author(s):  
O. Isik ◽  
C. Benlice ◽  
E. Gorgun

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