Personalized Medicine in Pain Management

2020 ◽  
pp. 133-139
Author(s):  
Stephen Campbell ◽  
Daniel Pak
Keyword(s):  
Pain Management ◽  
Personalized Medicine

scholarly journals Personalized pediatric anesthesia and pain management: problem-based review

2020 ◽  
Vol 21 (1) ◽  
pp. 55-73
Author(s):  
Senthil Packiasabapathy ◽  
Valluvan Rangasamy ◽  
Nicole Horn ◽  
Michele Hendrickson ◽  
Janelle Renschler ◽  
...  
Keyword(s):  
Pain Management ◽  
Personalized Medicine ◽  
Malignant Hyperthermia ◽  
Drug Response ◽  
Pediatric Anesthesia ◽  
Special Focus ◽  
Management Problem ◽  
Clinical Implementation ◽  
Catching Up ◽  
Prolonged Apnea

Pharmacogenetics, the genetic influence on the interpersonal variability in drug response, has enabled tailored pharmacotherapy and emerging ‘personalized medicine.’ Although oncology spearheaded the clinical implementation of personalized medicine, other specialties are rapidly catching up. In anesthesia, classical examples of genetically mediated idiosyncratic reactions have been long known (e.g., malignant hyperthermia and prolonged apnea after succinylcholine). The last two decades have witnessed an expanding body of pharmacogenetic evidence in anesthesia. This review highlights some of the prominent pharmacogenetic associations studied in anesthesia and pain management, with special focus on pediatric anesthesia.

scholarly journals COVID-19 Pandemic: Implications on Interventional Pain Practice—a Narrative Review

2020 ◽  
Vol 4S;23 (8;4S) ◽  
pp. S311-S318
Author(s):  
Sudhir Diwan
Keyword(s):  
Chronic Pain ◽  
Immune System ◽  
Pain Management ◽  
Personalized Medicine ◽  
Regenerative Medicine ◽  
Key Words ◽  
Normal Saline ◽  
Local Anesthetics ◽  
The Future ◽  
Interventional Pain Management

Background: The COVID-19 pandemic has emerged and has challenged us to look for alternatives to bring about a paradigm shift in interventional chronic pain management. As the disease lowers the body’s immune system, the use of medications that suppress the immune system are not recommended during the COVID-19 pandemic. Objective: The purpose of this study was to review medications other than steroids used for interventional pain management and the emphasis on mitigation of the untoward consequences of steroid injections on the immune system during the COVID-19 pandemic. Literature Search: The literature was searched for articles in English with key words COVID-19, immunity, steroid for pain management injections with steroid, local anesthetics, dextrose water, normal saline, pain and genetic medicine, pain, and regenerative medicine. The sources of articles were PubMed, Embase, and open Google search. Literature Review: The medications used for interventional pain management include steroids and opioids. The side effects of these medications are well known but have never been looked at as critically as they are now. Many other medications have been used for interventional pain procedures to relieve pain, such as dextrose water, normal saline solution, local anesthetics, and many adjuvants. Regarding regenerative therapy, despite plenty of evidence in literature, we have not yet considered it as a routine therapy for chronic pain injections. It is now time to move on beyond steroids and consider other types of medications and treatment options. The use of these medications in clinical practice is less auspicious, and thus more research is needed on the practical applications. Further areas for research include studies to determine definitive efficacy and safety assessment and determine whether or not the analgesic effects of these drugs are duration or dose-dependent. The optimal identification of candidates, volume, concentration, and intervals of injection are essential for routine application in interventional chronic pain practice. Conclusions: The future of interventional pain practice is trending toward regenerative medicine and genetic research. Numerous scientific studies have been conducted to investigate the genetic basis of phenotypic variability in individuals with different ethnic groups in terms of susceptibility to chronic pain, as well as response to treatment for the personalized medicine model. Despite the preliminary data on genetic variations, there is no evidence for the use of a pharmacogenomicsbased approach to personalized medicine for patients with chronic pain. The field of medicine therefore needs further research in pharmacogenetics, including large-scale prospective studies that focus on pain pathways. However, recent research, including larger studies and larger-scale genomic perspectives, may yield more promising findings in the future. The COVID-19 pandemic proved the need for medications with the most impact and least complications. Key words: COVID-19, steroid, pain injections, chronic pain, immune system, regenerative medicine

Genomics testing and personalized medicine in the preoperative setting: Can it change outcomes in postoperative pain management?

2020 ◽  
Vol 34 (2) ◽  
pp. 283-295
Author(s):  
Rahul Chaturvedi ◽  
Brenton Alexander ◽  
Alison M. A'Court ◽  
Ruth S. Waterman ◽  
Brittany N. Burton ◽  
...  
Keyword(s):  
Pain Management ◽  
Postoperative Pain ◽  
Personalized Medicine ◽  
Postoperative Pain Management ◽  
And Personalized Medicine

Personalized Medicine for Pain Management

2007 ◽  
pp. 539-542
Author(s):  
Paul J. Jannetto ◽  
Nancy C. Bratanow
Keyword(s):  
Pain Management ◽  
Personalized Medicine

Pharmacogenetics and Personalized Medicine in Pain Management

2016 ◽  
Vol 36 (3) ◽  
pp. 493-506 ◽  
Author(s):  
Lynn R. Webster ◽  
Inna Belfer
Keyword(s):  
Pain Management ◽  
Personalized Medicine ◽  
And Personalized Medicine

The real cost of pain management

Anaesthesia ◽  
2001 ◽  
Vol 56 (11) ◽  
pp. 1031-1033 ◽  
Author(s):  
C. J. Phillips
Keyword(s):  
Pain Management ◽  
The Real ◽  
Real Cost

Procedural Coding for Interventional Pain Management

2020 ◽  
Vol 23 (4) ◽  
pp. 100703
Author(s):  
Shantanu Warhadpande ◽  
Stephanie L. Dybul ◽  
Minhaj S. Khaja
Keyword(s):  
Pain Management ◽  
Interventional Pain Management

Older Patients' Stoicism Hinders Pain Management

2008 ◽  
Vol 41 (11) ◽  
pp. 31
Author(s):  
KATE JOHNSON
Keyword(s):  
Pain Management ◽  
Older Patients
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