Magnetic Nanoparticles as MRI Contrast Agents

2020 ◽  
pp. 49-91
Author(s):  
Ashish Avasthi ◽  
Carlos Caro ◽  
Esther Pozo‑Torres ◽  
Manuel Pernia Leal ◽  
María Luisa García‑Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals Correction to: Magnetic Nanoparticles as MRI Contrast Agents

2021 ◽  
Vol 379 (4) ◽  
Author(s):  
Ashish Avasthi ◽  
Carlos Caro ◽  
Esther Pozo-Torres ◽  
Manuel Pernia Leal ◽  
María Luisa García-Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

A correction to this paper has been published: https://doi.org/10.1007/s41061-021-00340-y

Macrophages mediated diagnosis of rheumatoid arthritis using fibrin based magnetic nanoparticles as MRI contrast agents

2017 ◽  
Vol 1861 (1) ◽  
pp. 2992-3001 ◽  
Author(s):  
Prabu Periyathambi ◽  
Thotapalli Parvathaleswara Sastry ◽  
Suresh Kumar Anandasadagopan ◽  
Kanagavel Manickavasagam
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

Carboxylated magnetic nanoparticles as MRI contrast agents: Relaxation measurements at different field strengths

2012 ◽  
Vol 324 (19) ◽  
pp. 3173-3180 ◽  
Author(s):  
Angéla Jedlovszky-Hajdú ◽  
Etelka Tombácz ◽  
István Bányai ◽  
Magor Babos ◽  
András Palkó
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Relaxation Measurements ◽  
Field Strengths

scholarly journals Magnetic Nanoparticles as MRI Contrast Agents

2020 ◽  
Vol 378 (3) ◽  
Author(s):  
Ashish Avasthi ◽  
Carlos Caro ◽  
Esther Pozo-Torres ◽  
Manuel Pernia Leal ◽  
María Luisa García-Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals Genetic encoding of targeted MRI contrast agents for in vivo tumor imaging

2019 ◽  
Author(s):  
Simone Schuerle ◽  
Maiko Furubayashi ◽  
Ava P. Soleimany ◽  
Tinotenda Gwisai ◽  
Wei Huang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Tumor Imaging ◽  
Mri Contrast Agents ◽  
Contrast Effects ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri ◽  
Targeted Mri

AbstractTumor-selective contrast agents have the potential to aid in the diagnosis and treatment of cancer using noninvasive imaging modalities such as magnetic resonance imaging (MRI). Such contrast agents can consist of magnetic nanoparticles incorporating functionalities that respond to cues specific to tumor environments. Genetically engineering magnetotactic bacteria to display peptides has been investigated as a means to produce contrast agents that combine the robust image contrast effects of magnetosomes with transgenic targeting peptides displayed on their surface. This work reports the first use of magnetic nanoparticles that display genetically-encoded pH low insertion peptide (pHLIP), a long peptide intended to enhance MRI contrast by targeting the extracellular acidity associated with the tumors. To demonstrate the modularity of this versatile platform to incorporate diverse targeting ligands by genetic engineering, we also incorporated the cyclic αv integrin-binding peptide iRGD into separate magnetosomes. Specifically, we investigate their potential for enhanced binding and tumor imaging both in vitro and in vivo. Our experiments indicate that these tailored magnetosomes retain their magnetic properties, making them well-suited as T2 contrast agents, while exhibiting increased binding compared to wild-type magnetosomes.

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