scholarly journals Correction to: Magnetic Nanoparticles as MRI Contrast Agents

2021 ◽  
Vol 379 (4) ◽  
Author(s):  
Ashish Avasthi ◽  
Carlos Caro ◽  
Esther Pozo-Torres ◽  
Manuel Pernia Leal ◽  
María Luisa García-Martín

A correction to this paper has been published: https://doi.org/10.1007/s41061-021-00340-y

2017 ◽  
Vol 1861 (1) ◽  
pp. 2992-3001 ◽  
Author(s):  
Prabu Periyathambi ◽  
Thotapalli Parvathaleswara Sastry ◽  
Suresh Kumar Anandasadagopan ◽  
Kanagavel Manickavasagam

2012 ◽  
Vol 324 (19) ◽  
pp. 3173-3180 ◽  
Author(s):  
Angéla Jedlovszky-Hajdú ◽  
Etelka Tombácz ◽  
István Bányai ◽  
Magor Babos ◽  
András Palkó

2020 ◽  
Vol 378 (3) ◽  
Author(s):  
Ashish Avasthi ◽  
Carlos Caro ◽  
Esther Pozo-Torres ◽  
Manuel Pernia Leal ◽  
María Luisa García-Martín

2019 ◽  
Author(s):  
Simone Schuerle ◽  
Maiko Furubayashi ◽  
Ava P. Soleimany ◽  
Tinotenda Gwisai ◽  
Wei Huang ◽  
...  

AbstractTumor-selective contrast agents have the potential to aid in the diagnosis and treatment of cancer using noninvasive imaging modalities such as magnetic resonance imaging (MRI). Such contrast agents can consist of magnetic nanoparticles incorporating functionalities that respond to cues specific to tumor environments. Genetically engineering magnetotactic bacteria to display peptides has been investigated as a means to produce contrast agents that combine the robust image contrast effects of magnetosomes with transgenic targeting peptides displayed on their surface. This work reports the first use of magnetic nanoparticles that display genetically-encoded pH low insertion peptide (pHLIP), a long peptide intended to enhance MRI contrast by targeting the extracellular acidity associated with the tumors. To demonstrate the modularity of this versatile platform to incorporate diverse targeting ligands by genetic engineering, we also incorporated the cyclic αv integrin-binding peptide iRGD into separate magnetosomes. Specifically, we investigate their potential for enhanced binding and tumor imaging both in vitro and in vivo. Our experiments indicate that these tailored magnetosomes retain their magnetic properties, making them well-suited as T2 contrast agents, while exhibiting increased binding compared to wild-type magnetosomes.


Author(s):  
Ashish Avasthi ◽  
Carlos Caro ◽  
Esther Pozo‑Torres ◽  
Manuel Pernia Leal ◽  
María Luisa García‑Martín

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