Pleomorphic Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a group of soft tissue sarcomas that share a common feature of primitive skeletal muscle differentiation. Three main subtypes have been characterized: embryonal, alveolar, and pleomorphic. Presentation and prognosis of RMS are highly variable, depending on anatomic location, subtype, and risk stratification. Currently, treatment centers on systemic control with cytotoxic chemotherapy and local control with surgery and/or therapeutic radiation. This review contains 3 figures, 10 tables and 50 references Key words: alveolar rhabdomyosarcoma, embryonal rhabdomyosarcoma, pediatric soft tissue sarcoma, pleomorphic rhabdomyosarcoma, rhabdomyosarcona, t(2;13), t(1;13)

Download Full-text

Pleomorphic rhabdomyosarcoma of the cerebellopontine angle in an adult: a review of literature

BMJ Case Reports ◽

10.1136/bcr-2013-203257 ◽

2014 ◽

Vol 2014 (jan30 1) ◽

pp. bcr2013203257-bcr2013203257 ◽

Cited By ~ 6

Author(s):

F. Caporlingua ◽

G. Lapadula ◽

M. Antonelli ◽

P. Missori

Keyword(s):

Cerebellopontine Angle ◽

Review Of Literature ◽

Pleomorphic Rhabdomyosarcoma

Download Full-text

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

The Journal of Pathology ◽

10.1002/path.2748 ◽

2010 ◽

Vol 222 (2) ◽

pp. 129-137 ◽

Cited By ~ 58

Author(s):

Brendan Doyle ◽

Jennifer P Morton ◽

David W Delaney ◽

Rachel A Ridgway ◽

Julie A Wilkins ◽

...

Keyword(s):

Mouse Model ◽

P53 Mutation ◽

Pleomorphic Rhabdomyosarcoma

Download Full-text

PLEOMORPHIC RHABDOMYOSARCOMA IN THE HEAD AND NECK REGION: A RARE CASE REPORT

10.36106/gjra/9809218 ◽

2021 ◽

pp. 38-40

Author(s):

S. Kanimozhi ◽

P. Pooja sri ◽

P. Karthika ◽

M. Sathish Kumar ◽

A. Mathan Mohan

Keyword(s):

Head And Neck ◽

Rare Case ◽

Neck Region ◽

Undifferentiated Carcinoma ◽

Biological Behavior ◽

Patient Reported ◽

Rare Case Report ◽

Malignant Mesenchymal Tumor ◽

Histological Variant ◽

Pleomorphic Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a rare, aggressive, malignant mesenchymal tumor of skeletal muscle cells. The pleomorphic histological variant of RMS occurs in adults beyond 45years of age and represents the most aggressive subtype with an incidence of approximately 0.44/100,000. The diagnosis of RMS is difcult with the 5year overall survival rate less than 50%. It presents varied clinical and biological behavior and requires individualized management. The common region of metastasis includes lymph nodes, lungs and bone marrow. Here we report a case of pleomorphic rhabdomyosarcoma in 58year old female. The patient reported with a swelling in the neck region and had a history of surgical treatment for ovarian tumor. Histopathology ndings revealed metastatic undifferentiated carcinoma. The case was positive for immunohistochemistry markers and their ndings are diagnosed as pleomorphic rhabdomyosarcoma. This is a rare case of RMS which had metastasized to head and neck and this article emphasizes the importance of IHC in accurate and clear diagnosis of RMS.

Download Full-text