scholarly journals A Recovery Algorithm and Pooling Designs for One-Stage Noisy Group Testing Under the Probabilistic Framework

Author(s):  
Yining Liu ◽  
Sachin Kadyan ◽  
Itsik Pe’er
2021 ◽  
Author(s):  
Yining Liu ◽  
Sachin Kadyan ◽  
Itsik Pe’er

AbstractGroup testing saves time and resources by testing each pre-assigned group instead of each individual, and one-stage group testing emerged as essential for cost-effectively controlling the current COVID-19 pandemic. Yet, the practical challenge of adjusting pooling designs based on infection rate has not been systematically addressed. In particular, there are both theoretical interests and practical motivation to analyze one-stage group testing at finite, practical problem sizes, rather than asymptotic ones, under noisy, rather than perfect tests, and when the number of positives is randomly distributed, rather than fixed.Here, we study noisy group testing under the probabilistic framework by modeling the infection vector as a random vector with Bernoulli entries. Our main contributions include a practical one-stage group testing protocol guided by maximizing pool entropy and a maximum-likelihood recovery algorithm under the probabilistic framework. Our findings high-light the implications of introducing randomness to the infection vectors – we find that the combinatorial structure of the pooling designs plays a less important role than the parameters such as pool size and redundancy.


1999 ◽  
Vol 36 (04) ◽  
pp. 951-964
Author(s):  
J. K. Percus ◽  
O. E. Percus ◽  
W. J. Bruno ◽  
D. C. Torney

We analyse the expected performance of various group testing, or pooling, designs. The context is that of identifying characterized clones in a large collection of clones. Here we choose as performance criterion the expected number of unresolved ‘negative’ clones, and we aim to minimize this quantity. Technically, long inclusion–exclusion summations are encountered which, aside from being computationally demanding, give little inkling of the qualitative effect of parametric control on the pooling strategy. We show that readily-interpreted re-summation can be performed, leading to asymptotic forms and systematic corrections. We apply our results to randomized designs, illustrating how they might be implemented for approximating combinatorial formulae.


1999 ◽  
Vol 36 (4) ◽  
pp. 951-964 ◽  
Author(s):  
J. K. Percus ◽  
O. E. Percus ◽  
W. J. Bruno ◽  
D. C. Torney

We analyse the expected performance of various group testing, or pooling, designs. The context is that of identifying characterized clones in a large collection of clones. Here we choose as performance criterion the expected number of unresolved ‘negative’ clones, and we aim to minimize this quantity. Technically, long inclusion–exclusion summations are encountered which, aside from being computationally demanding, give little inkling of the qualitative effect of parametric control on the pooling strategy. We show that readily-interpreted re-summation can be performed, leading to asymptotic forms and systematic corrections. We apply our results to randomized designs, illustrating how they might be implemented for approximating combinatorial formulae.


2013 ◽  
Vol 791-793 ◽  
pp. 892-896
Author(s):  
Hong Hao Zhao ◽  
Fan Bo Meng ◽  
Qing Qi Zhao ◽  
Wei Zhe Ma ◽  
Zhi Chao Lin ◽  
...  

In this paper, we address the problem of real-time network traffic monitoring in the communication network of smart grid. And we propose an effective distributed network traffic monitoring approach. In our algorithm, instead of measuring all the origin-destination pairs, we just need to measure partial origin-destination pairs that flows our communication network. From the measured origin-destination pairs, we can obtain all the origin-destination pairs via our recovery algorithm. Finally, we validate the properties of our method by real network data.


2009 ◽  
Vol 01 (02) ◽  
pp. 235-251 ◽  
Author(s):  
WEIWEI LANG ◽  
YUEXUAN WANG ◽  
JAMES YU ◽  
SUOGANG GAO ◽  
WEILI WU

In this paper, we define an α-almost (k; 2e + 1)-separable matrix and an α-almostke-disjunct matrix. Using their complements, we devise algorithms for fault-tolerant trivial two-stage group tests (pooling designs) for k-complexes. We derive the expected values for the given algorithms to identify all such positive complexes.


2021 ◽  
Vol 13 (589) ◽  
pp. eabf1568 ◽  
Author(s):  
Brian Cleary ◽  
James A. Hay ◽  
Brendan Blumenstiel ◽  
Maegan Harden ◽  
Michelle Cipicchio ◽  
...  

Virological testing is central to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) containment, but many settings face severe limitations on testing. Group testing offers a way to increase throughput by testing pools of combined samples; however, most proposed designs have not yet addressed key concerns over sensitivity loss and implementation feasibility. Here, we combined a mathematical model of epidemic spread and empirically derived viral kinetics for SARS-CoV-2 infections to identify pooling designs that are robust to changes in prevalence and to ratify sensitivity losses against the time course of individual infections. We show that prevalence can be accurately estimated across a broad range, from 0.02 to 20%, using only a few dozen pooled tests and using up to 400 times fewer tests than would be needed for individual identification. We then exhaustively evaluated the ability of different pooling designs to maximize the number of detected infections under various resource constraints, finding that simple pooling designs can identify up to 20 times as many true positives as individual testing with a given budget. Crucially, we confirmed that our theoretical results can be translated into practice using pooled human nasopharyngeal specimens by accurately estimating a 1% prevalence among 2304 samples using only 48 tests and through pooled sample identification in a panel of 960 samples. Our results show that accounting for variation in sampled viral loads provides a nuanced picture of how pooling affects sensitivity to detect infections. Using simple, practical group testing designs can vastly increase surveillance capabilities in resource-limited settings.


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