Synthesis, In Silico Studies, and Biological Evaluation of 1,3,4-Oxadiazino Indole Derivatives

2021 ◽  
pp. 239-248
Author(s):  
K. Pavani ◽  
K. Swathi
Keyword(s):  
In Silico ◽  
Biological Evaluation ◽  
Indole Derivatives ◽  
In Silico Studies

scholarly journals Synthesis, biological evaluation, and in silico studies of novel chalcone- and pyrazoline-based 1,3,5-triazines as potential anticancer agents

RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 34114-34129
Author(s):  
Leydi M. Moreno ◽  
Jairo Quiroga ◽  
Rodrigo Abonia ◽  
Antonino Lauria ◽  
Annamaria Martorana ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
In Silico ◽  
Biological Evaluation ◽  
In Silico Studies

A novel series of triazin-chalcones (7,8)a–g and triazin-N-(3,5-dichlorophenyl)pyrazolines (9,10)a–g were synthesized and evaluated for their anticancer activity against nine different cancer strains.

Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies

2020 ◽  
Vol 96 ◽  
pp. 103610 ◽  
Author(s):  
Nayera W. Hassan ◽  
Manal N. Saudi ◽  
Yasser S. Abdel-Ghany ◽  
Azza Ismail ◽  
Perihan A. Elzahhar ◽  
...  
Keyword(s):  
In Silico ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
In Silico Studies

Synthesis, In Vitro Biological Evaluation and In Silico Studies of Some New Heterocyclic Schiff Bases

2018 ◽  
Vol 3 (47) ◽  
pp. 13517-13525 ◽  
Author(s):  
Rizwan Arif ◽  
Amaduddin ◽  
Sarfraz Ahmed ◽  
Saami Ahmed ◽  
Mohammad Abid ◽  
...  
Keyword(s):  
Schiff Bases ◽  
In Silico ◽  
Biological Evaluation ◽  
In Silico Studies ◽  
Heterocyclic Schiff Bases

Synthesis, Biological Evaluation and In Silico Studies of 1,2,4‐Triazole and 1,3,4‐Thiadiazole Derivatives as Antiherpetic Agents

2019 ◽  
Vol 4 (21) ◽  
pp. 6421-6428 ◽  
Author(s):  
Hebat‐Allah M. Goma'a ◽  
Mariam A. Ghaly ◽  
Laila A. Abou‐zeid ◽  
Farid A. Badria ◽  
Ihsan A. Shehata ◽  
...  
Keyword(s):  
In Silico ◽  
Biological Evaluation ◽  
In Silico Studies ◽  
Thiadiazole Derivatives

scholarly journals Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 666 ◽  
Author(s):  
Katerina Georgousaki ◽  
Nikolaos Tsafantakis ◽  
Sentiljana Gumeni ◽  
George Lambrinidis ◽  
Victor González-Menéndez ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
In Silico ◽  
Functional Module ◽  
Biological Evaluation ◽  
Bjerkandera Adusta ◽  
Benzoic Acid Derivatives ◽  
Human Foreskin Fibroblasts ◽  
In Silico Studies ◽  
Network Modules ◽  
Ubiquitin Proteasome

A main cellular functional module that becomes dysfunctional during aging is the proteostasis network. In the present study, we show that benzoic acid derivatives isolated from Bjerkandera adusta promote the activity of the two main protein degradation systems, namely the ubiquitin-proteasome (UPP) and especially the autophagy-lysosome pathway (ALP) in human foreskin fibroblasts. Our findings were further supported by in silico studies, where all compounds were found to be putative binders of both cathepsins B and L. Among them, compound 3 (3-chloro-4-methoxybenzoic acid) showed the most potent interaction with both enzymes, which justifies the strong activation of cathepsins B and L (467.3 ± 3.9%) on cell-based assays. Considering that the activity of both the UPP and ALP pathways decreases with aging, our results suggest that the hydroxybenzoic acid scaffold could be considered as a promising candidate for the development of novel modulators of the proteostasis network, and likely of anti-aging agents.

Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids

2019 ◽  
Vol 1175 ◽  
pp. 577-586 ◽  
Author(s):  
Rajendran Sribalan ◽  
Govindharasu Banuppriya ◽  
Maruthan Kirubavathi ◽  
Vediappen Padmini
Keyword(s):  
In Silico ◽  
Biological Evaluation ◽  
In Silico Studies
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