Co-designing Resources for Knowledge-Based Self-reflection for People Living with Parkinson’s Disease to Better Enable Independent Living

The Impact of Parkinson’s Disease and Chronic Stroke on Simple Multitasking Abilities

Journal of Addiction Research ◽

10.33140/jar/02/02/00007 ◽

2018 ◽

Vol 2 (2) ◽

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Independent Living ◽

Chronic Stroke ◽

Control Group ◽

Timed Up And Go ◽

Significant Deterioration ◽

Indian Origin ◽

Time Required ◽

The Impact

It is hypothesised that Parkinson’s disease and chronic strokes may interfere with patient’s ability to multitask. The aim of the study is to explore the impact of chronic stroke or Parkinson’s on simple multitasking abilities. Both diseases cause the inability to perform simple activities such as walking and mental mathematics simultaneously. In a controlled sample of 15 patients of Indian origin with either chronic stroke or Parkinson’s disease it was observed that there was a significant deterioration in the ability to multitask (increase in time taken to multitask between Timed up and Go (TUG) and Dual Timed up and Go (Dual TUG) versus a normal control group). The study found that the average increase in time required to complete the tests was 49% (for chronic stroke patients) and 36 % (for patients with Parkinson’s disease) as compared to a normal baseline of less than 10%. In patients with chronic stroke or Parkinson’s disease, special attention must be paid to these impairments as they significantly affect independent living.

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Application Research Progress of Neuromodulation Technology in the Treatment of Freezing Gait in Parkinson's Disease

Journal of Clinical Medicine Research ◽

10.32629/jcmr.v1i3.244 ◽

2021 ◽

Vol 1 (3) ◽

Author(s):

Guolin Shi ◽

Ninghui Zhao ◽

Tingting Wu

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Independent Living ◽

Implantable Devices ◽

Research Progress ◽

Application Research ◽

Chemical Methods ◽

Obvious Effect

Freezing gait is a common clinical symptom in patients with Parkinson's disease. It tends to get worse with the progress of the disease, causing the patients to fall easily, which is one of the important reasons for the loss of independent living ability. The treatment of frozen gait is very complicated, and drug treatment has no obvious effect. Neuromodulation technology is currently an effective method for clinical treatment of frozen gait in Parkinson's disease. This technology mainly uses implantable devices and non-implantable devices, and uses electrical or chemical methods to correct frozen gait, which helps to improve the quality of life of patients with Parkinson's disease. This article focuses on the application research of neuromodulation technology in the treatment of freezing gait in Parkinson's disease.

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Predictors of clinically significant quality of life impairment in Parkinson’s disease

npj Parkinson s Disease ◽

10.1038/s41531-021-00256-w ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Santos García D. ◽

Teresa de Deus Fonticoba ◽

Carlos Cores ◽

Guillermo Muñoz ◽

Jose M. Paz González ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Independent Living ◽

Motor Impairment ◽

Control Group ◽

Health Related Qol ◽

Clinically Significant

AbstractQuality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson’s disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months ± 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 ≥ 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 ± 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 ± 13 to 20.3 ± 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829–0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422–12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053–1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027–1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer–Lemeshow test, p = 0.665; R2 = 0.655). An increase in ≥5 and ≥10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663–17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975–22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.

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Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease

The Journal of Laryngology & Otology ◽

10.1017/s0022215106002787 ◽

2005 ◽

pp. 1

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Transcranial Magnetic Stimulation ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation ◽

Voice And Speech

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Emerging Drugs and Targets for Parkinson's Disease

10.1039/9781849737357 ◽

2013 ◽

Cited By ~ 3

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease

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Evaluation of Efferent Auditory System and Hearing Quality in Parkinson's Disease: Is the Difficulty in Speech Understanding in Complex Listening Conditions Related to Neural Degeneration or Aging?

Journal of Speech Language and Hearing Research ◽

10.1044/2020_jslhr-20-00337 ◽

2020 ◽

pp. 1-9

Author(s):

Nuriye Yıldırım Gökay ◽

Bülent Gündüz ◽

Fatih Söke ◽

Recep Karamert

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Auditory System ◽

Otoacoustic Emissions ◽

Pure Tone ◽

Pure Tone Audiometry ◽

Auditory Pathway ◽

Normal Hearing ◽

System Function ◽

Distortion Product

Purpose The effects of neurological diseases on the auditory system have been a notable issue for investigators because the auditory pathway is closely associated with neural systems. The purposes of this study are to evaluate the efferent auditory system function and hearing quality in Parkinson's disease (PD) and to compare the findings with age-matched individuals without PD to present a perspective on aging. Method The study included 35 individuals with PD (mean age of 48.50 ± 8.00 years) and 35 normal-hearing peers (mean age of 49 ± 10 years). The following tests were administered for all participants: the first section of the Speech, Spatial and Qualities of Hearing Scale; pure-tone audiometry, speech audiometry, tympanometry, and acoustic reflexes; and distortion product otoacoustic emissions (DPOAEs) and contralateral suppression of DPOAEs. SPSS Version 25 was used for statistical analyses, and values of p < .05 were considered statistically significant. Results There were no statistically significant differences in the pure-tone audiometry thresholds and DPOAE responses between the individuals with PD and their normal-hearing peers ( p = .732). However, statistically significant differences were found between the groups in suppression levels of DPOAEs and hearing quality ( p < .05). In addition, a statistically significant and positive correlation was found between the amount of suppression at some frequencies and the Speech, Spatial and Qualities of Hearing Scale scores. Conclusions This study indicates that medial olivocochlear efferent system function and the hearing quality of individuals with PD were affected adversely due to the results of PD pathophysiology on the hearing system. For optimal intervention and follow-up, tasks related to hearing quality in daily life can also be added to therapies for PD.

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