Recent Medical and Surgical Treatments for Parkinson's Disease

1999 ◽  
Vol 4 (1) ◽  
pp. 9-12
Author(s):  
Philip M. Green
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Surgical Treatments

Long-Term Effects of Medical and Surgical Treatments on Parkinson's Disease

1994 ◽  
Vol 62 (1-4) ◽  
pp. 85-89
Author(s):  
Fiacro Jimenez ◽  
Francisco Velasco ◽  
Marcos Velasco ◽  
Ana Luisa Velasco
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Effects ◽  
Surgical Treatments

scholarly journals The development of visual neuroimaging research of acupuncture in the treatment of Parkinson’s disease

2019 ◽  
Vol 5 (3) ◽  
pp. 161-168 ◽  
Author(s):  
Yuan Yang ◽  
Suhua Miao ◽  
Rongsong Zhou ◽  
Yu Ma ◽  
Yuqi Zhang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuronal Activity ◽  
Structural Changes ◽  
Neurodegenerative Disorder ◽  
Cerebral Metabolism ◽  
Experimental Studies ◽  
Brain Regions ◽  
Imaging Studies ◽  
Surgical Treatments

Parkinson’s disease (PD) is a progressive neurodegenerative disorder commonly observed in middle-aged and elderly. Currently, its etiology and pathogenesis are still not completely understood. It is associated with many symptoms that severely affect patients’ health and quality of life. At present, the PD clinical treatment mainly aimed to alleviate symptoms, and both medicinal and surgical treatments have side effects and treatment blind spots. The use of acupuncture for the treatment of PD is relatively widespread, and its safety and efficacy have been gradually accepted by the public and medical professions. However, the efficacy of acupuncture in experimental studies remains controversial. Therefore, this paper reviews imaging studies on the use of acupuncture for the treatment of PD. From the study, it shows that acupuncture can improve the neuronal activity, activate the neuronal activity in damaged brain regions, affect relevant neural networks and brain circulation, improve cerebral metabolism, and cause structural changes in related brain regions. Intuitive and visible imaging studies provide objective bases on the use of acupuncture for the treatment of PD.

BILATERAL SUBTHALAMIC DEEP BRAIN STIMULATION IN A PATIENT WITH PARKINSON'S DISEASE WHO HAD PREVIOUSLY UNDERGONE THALAMOTOMY AND AUTOLOGOUS ADRENAL GRAFTING IN THE CAUDATE NUCLEUS

Neurosurgery ◽  
2006 ◽  
Vol 59 (5) ◽  
pp. E1140-E1140 ◽  
Author(s):  
Francesco Vergani ◽  
Andrea Landi ◽  
Angelo Antonini ◽  
Erik P. Sganzerla
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Disease Rating ◽  
Noticeable Reduction ◽  
Surgical Treatments ◽  
Deep Brain

Abstract OBJECTIVE Subthalamic (Stn) deep brain stimulation (DBS) is a valid surgical therapy for the treatment of severe Parkinson's disease. In recent years, StnDBS has been proposed for patients who previously received other surgical treatments, such as thalamotomy and pallidotomy. Nonetheless, there is no consensus about the indications of DBS in patients who previously underwent surgery. To the best of our knowledge this is the first reported case of a patient treated with DBS after previous thalamotomy and adrenal grafting. CLINICAL PRESENTATION A 62-year-old man with a long history (more than 30 yr) of Parkinson's disease received unilateral thalamotomy and autologous adrenal graft on two independent occasions. Thalamotomy led to a significant improvement, although limited to the control of contralateral tremor. The autologous adrenal graft was of no benefit. For the subsequent occurrence of L-dopa related dyskinesias and severe “off” periods, the patient was referred to our center for StnDBS. INTERVENTION The patient underwent bilateral StnDBS, obtaining a satisfactory improvement of rigidity and bradykinesia on both sides. The 1-year follow-up evaluation showed a 46% improvement in the Unified Parkinson's Disease Rating Scale motor section, along with a noticeable reduction in antiparkinsonian therapy (81%). CONCLUSION This case is consistent with previous reports from the literature, suggesting that StnDBS is feasible and safe, even in patients who previously received other surgical treatments for Parkinson's disease, such as thalamotomy or cell grafting.

scholarly journals Motor-cognitive approach and aerobic training: a synergism for rehabilitative intervention in Parkinson's disease

2020 ◽  
Vol 10 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Davide Ferrazzoli ◽  
Paola Ortelli ◽  
Alberto Cucca ◽  
Leila Bakdounes ◽  
Margherita Canesi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Behavior ◽  
Models Of Care ◽  
Economic Consequences ◽  
Current Evidence ◽  
Pharmacological Intervention ◽  
Cognitive Approach ◽  
Rehabilitative Intervention ◽  
Surgical Treatments

Parkinson's disease (PD) results in a complex deterioration of motor behavior. Effective pharmacological or surgical treatments addressing the whole spectrum of both motor and cognitive symptoms are lacking. The cumulative functional impairment may have devastating socio-economic consequences on both patients and caregivers. Comprehensive models of care based on multidisciplinary approaches may succeed in better addressing the overall complexity of PD. Neurorehabilitation is a highly promising non-pharmacological intervention for managing PD. The scientific rationale beyond rehabilitation and its practical applicability remain to be established. In the present perspective, we aim to discuss the current evidence supporting integrated motor-cognitive and aerobic rehabilitation approaches for patients with PD while suggesting a practical framework to optimize this intervention in the next future.

Review of Deep Brain Stimulation Micro-Electrodes

2012 ◽  
Vol 500 ◽  
pp. 596-602 ◽  
Author(s):  
Jun Zhou ◽  
Pei Chao Liu ◽  
Saif Ullah ◽  
Yun Feng Zhang ◽  
Shou Lei Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Surgical Treatments ◽  
Resistance Movement ◽  
Deep Brain

Currently, deep brain stimulation (DBS) is one of the most effective surgical treatments of treating serious stubborn resistance movement disorders (such as Parkinson's disease, essential tremor and dystonia, etc.). The nerve probe has been greatly favored by the authorities and scientists with the respect to the role it acted as the main brain stimulation tool. This article mainly introduces the materials of brain stimulated micro-electrode, the matched specifications and the evaluation on the compound functions in the developing course. The application prosperity and its development trendy will also be included with the intention to help people gain more systematic acknowledgement on the electrodes for deep brain stimulation.

scholarly journals The Future of Surgical Treatments for Parkinson’s Disease

2018 ◽  
Vol 8 (s1) ◽  
pp. S79-S83 ◽  
Author(s):  
Darrin J. Lee ◽  
Andres M. Lozano
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
The Future ◽  
Surgical Treatments

Management of Parkinson's disease in older women

2008 ◽  
Vol 14 (1) ◽  
pp. 38-39 ◽  
Author(s):  
Molly Daymont Price ◽  
Lisa M Shulman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Older Women ◽  
Elderly Women ◽  
Treatment Strategies ◽  
Specific Patient ◽  
Gender And Age ◽  
Surgical Treatments ◽  
Relationship Of ◽  
The Relationship

Elderly women with Parkinson's disease (PD) represent a specific patient population that may benefit from individualized treatment strategies. PD has been shown to occur approximately twice as often in men than in women, resulting in theories regarding estrogen being protective against the disease and as a potential treatment strategy. Given women's longer life expectancy they are more likely to reach an age where antiparkinsonian medications are associated with side-effects. This paper will review medical and surgical treatments as well as the relationship of gender and age with respect to the management of PD.

scholarly journals Gene Therapy for Parkinson's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Rachel Denyer ◽  
Michael R. Douglas
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Dopaminergic Neurons ◽  
Symptomatic Relief ◽  
Disease Process ◽  
Treatment Modalities ◽  
Theoretical Approaches ◽  
Novel Approaches ◽  
Surgical Treatments

Current pharmacological and surgical treatments for Parkinson's disease offer symptomatic improvements to those suffering from this incurable degenerative neurological disorder, but none of these has convincingly shown effects on disease progression. Novel approaches based on gene therapy have several potential advantages over conventional treatment modalities. These could be used to provide more consistent dopamine supplementation, potentially providing superior symptomatic relief with fewer side effects. More radically, gene therapy could be used to correct the imbalances in basal ganglia circuitry associated with the symptoms of Parkinson's disease, or to preserve or restore dopaminergic neurons lost during the disease process itself. The latter neuroprotective approach is the most exciting, as it could theoretically be disease modifying rather than simply symptom alleviating. Gene therapy agents using these approaches are currently making the transition from the laboratory to the bedside. This paper summarises the theoretical approaches to gene therapy for Parkinson's disease and the findings of clinical trials in this rapidly changing field.

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