Subependymal Nodules of Tuberous Sclerosis

2022 ◽  
pp. 269-272
Author(s):  
John M. Stern ◽  
Noriko Salamon
Keyword(s):  
Tuberous Sclerosis ◽  
Subependymal Nodules

La valutazione RM della sclerosi tuberosa

2003 ◽  
Vol 16 (3) ◽  
pp. 547-550
Author(s):  
C. Uggetti
Keyword(s):  
Tuberous Sclerosis ◽  
Neoplastic Transformation ◽  
Pathogenetic Mechanism ◽  
Clinical Correlations ◽  
Asymptomatic Subjects ◽  
Changes Over Time ◽  
Over Time ◽  
Subependymal Nodules ◽  
Rule Out

The myriad brain abnormalities characterising tuberous sclerosis are all the result of the same pathogenetic mechanism, a genetic impairment of the germinative matrix. MR scanning plays a major role in the diagnosis and follow-up of patients who must be monitored up to the age of twenty to rule out the possible neoplastic transformation of subependymal nodules. MR scans should also be offered to the parents of children with tuberous sclerosis to disclose asymptomatic subjects. Starting from a total of 36 scans in a personal series of 24 patients, we describe the best sequences for brain investigation, the different MR findings and their changes over time with possible clinical correlations.

Subependymal nodules and giant cell tumours in tuberous sclerosis complex patients: prevalence on MRI in relation to gene mutation

2012 ◽  
Vol 29 (2) ◽  
pp. 249-254 ◽  
Author(s):  
Caterina Michelozzi ◽  
Giovanni Di Leo ◽  
Federica Galli ◽  
Fabiane Silva Barbosa ◽  
Francesca Labriola ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Giant Cell ◽  
Gene Mutation ◽  
Tuberous Sclerosis Complex ◽  
Complex Patients ◽  
Giant Cell Tumours ◽  
Subependymal Nodules

Standardized Whole Brain Mapping of Tubers and Subependymal Nodules in Tuberous Sclerosis Complex

2004 ◽  
Vol 19 (9) ◽  
pp. 658-665 ◽  
Author(s):  
Khanum Ridler ◽  
John Suckling ◽  
Nicholas Higgins ◽  
Patrick Bolton ◽  
Edward Bullmore
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Brain Mapping ◽  
Whole Brain ◽  
Subependymal Nodules

Comparison of MRI Sequences to CT in Identification of Calcified Subependymal Nodules in Tuberous Sclerosis Patients (P03.134)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P03.134-P03.134 ◽  
Author(s):  
A. McGregor ◽  
E. Caron ◽  
F. Perkins ◽  
J. Wheless ◽  
A. Choudhri
Keyword(s):  
Tuberous Sclerosis ◽  
Mri Sequences ◽  
Subependymal Nodules

Tuberous sclerosis complex without tubers and subependymal nodules: a phenotype-genotype study

2013 ◽  
Vol 86 (2) ◽  
pp. 149-154 ◽  
Author(s):  
S. Boronat ◽  
E.A. Shaaya ◽  
C.M. Doherty ◽  
P. Caruso ◽  
E.A. Thiele
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Subependymal Nodules

scholarly journals Nonfunctional Islet Cell Tumor of the Pancreas in a Patient with Tuberous Sclerosis: A Case Report with Literature Review

2014 ◽  
Vol 4 ◽  
pp. 3 ◽  
Author(s):  
Aysegul Cansu ◽  
Ali Ahmetoglu ◽  
Sibel Kul ◽  
Dilek Uzman ◽  
Safak Ersoz
Keyword(s):  
Case Report ◽  
Tuberous Sclerosis ◽  
Islet Cell ◽  
Histopathological Examination ◽  
Islet Cell Tumor ◽  
Large Mass ◽  
Cell Tumor ◽  
Islet Cell Tumors ◽  
Appropriate Treatment ◽  
Subependymal Nodules

Islet cell tumors (ICTs) are rare tumors of the pancreas. Association of this type of tumor with tuberous sclerosis is extremely rare. Only 13 cases of pancreatic ICT with tuberous sclerosis have so far been documented in the literature. However, awareness of the association of tuberous sclerosis and ICT is important for early diagnosis and appropriate treatment of this condition. This article presents the case of a 63-year-old female with angiomyolipoma (AML) of the kidney and liver, calcified subependymal nodules and a large mass in the pancreas, which was proven to be an ICT on histopathological examination.

The ability of high field strength 7-T magnetic resonance imaging to reveal previously uncharacterized brain lesions in patients with tuberous sclerosis complex

2013 ◽  
Vol 11 (3) ◽  
pp. 268-273 ◽  
Author(s):  
Jason R. Chalifoux ◽  
Nissa Perry ◽  
Joel S. Katz ◽  
Graham C. Wiggins ◽  
Jonathan Roth ◽  
...  
Keyword(s):  
Field Strength ◽  
Caudate Nucleus ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
High Field ◽  
High Field Strength ◽  
Conventional Mri ◽  
Institutional Review ◽  
Electrophysiological Recordings ◽  
Subependymal Nodules

Object Tuberous sclerosis complex (TSC) brain pathology is characterized on MRI by cortical tubers, subependymal nodules, and subependymal giant cell astrocytomas. Seizures, the prominent feature of TSC, are frequently intractable to medical therapy and, in many patients, resection of tubers results in seizure control. However, in approximately 40% of patients, resection of tubers does not control seizures. This fact, as well as evidence from invasive electrophysiological recordings and experimental animal models, suggests that in patients with TSC, there may be extratuberal epileptogenic brain that does not display any apparent abnormality on conventional MRI. The authors hypothesized that high field strength MRI might uncover lesions not seen on conventional MRI in these patients. Methods Institutional review board approval was obtained to scan 4 patients with TSC (ages 18–26 years) in a 7-T MR unit. Optimized 7-T sequences, including T1- and T2-weighted, FLAIR, SPACE FLAIR, T2*, and MPRAGE studies, were performed. Imaging studies were compared with identical sequences performed using a conventional 1.5-T MR scanner. Results In all 4 patients, there was improved visualization of the findings demonstrated on conventional imaging. Importantly, new lesions were detected in all 4 patients, which were not well visualized with conventional MRI. Newly detected lesions included microtubers, radial glial signal abnormalities, subependymal nodules arising from the caudate nucleus, and caudate nucleus lesions. Conclusions High field strength MRI detects previously uncharacterized lesions in patients with TSC and allows better detection and delineation of subtle abnormalities. In addition, the data demonstrate a compelling relationship between intraventricular lesions and the caudate nucleus. These data support previous electrophysiological and animal-model findings that demonstrate neurological pathology beyond the conventionally detected lesions in TSC.

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