In vitro activity of novel sulphonic derivatives of distamicyn A

1992 ◽  
pp. 455-458 ◽  
Author(s):  
M. Mariani ◽  
A. Paio ◽  
M. Ciomei ◽  
W. Pastori ◽  
C. Franzetti ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Derivatives Of

Antimycobacterial 3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones substituted on phenyl and benzoxazine moiety in position 6

2011 ◽  
Vol 65 (3) ◽  
Author(s):  
Eva Petrlíková ◽  
Karel Waisser ◽  
Rafael Doležal ◽  
Pavel Holý ◽  
Jiří Gregor ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Antimycobacterial Activity ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Derivatives Of

AbstractA series of forty-five derivatives of 3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and forty-five derivatives of 3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones was synthesised. The compounds exhibited in-vitro activity against Mycobacterium tuberculosis, M. kansasii (two strains), and M. avium. The most active derivatives were more active than isonicotinhydrazide (INH). The quantitative relationships between the structure and antimycobacterial activity were calculated. The activity against M. tuberculosis increased with the lipophilicity of the substituents.

In vitro activity of novel derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile against human cytomegalovirus

2019 ◽  
Vol 28 (8) ◽  
pp. 1205-1211 ◽  
Author(s):  
Maryna V. Kachaeva ◽  
Stepan G. Pilyo ◽  
Caroll B. Hartline ◽  
Emma A. Harden ◽  
Mark N. Prichard ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Derivatives Of

In Vitro Activity of Novel 5-Carbonyl Derivatives of 3-Phenyl-3-(1H-imidazol-1-ylmethyl)-2-methyl-isoxazolidines

1988 ◽  
Vol 544 (1 Antifungal Dr) ◽  
pp. 396-399 ◽  
Author(s):  
GRACE A. BENNETT ◽  
GEORGE B. MULLEN ◽  
THOMAS R. DeCORY,b ◽  
STANLEY D. ALLEN ◽  
JEFFREY T. MITCHELL ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Carbonyl Derivatives ◽  
Derivatives Of

scholarly journals 3-Keto-11,12-carbazate Derivatives of 6-0-Methylerythromycin A Synthesis and In Vitro Activity.

1996 ◽  
Vol 49 (5) ◽  
pp. 465-477 ◽  
Author(s):  
GEORGE GRIESGRABER ◽  
YAT SUN OR ◽  
DANIEL T. W. CHU ◽  
ANGELA M. NILIUS ◽  
PAULINE M. JOHNSON ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Derivatives Of

Synthesis of spin-labeled analogues of drug molecules with potential action on neuroreceptors

1983 ◽  
Vol 61 (11) ◽  
pp. 2540-2543 ◽  
Author(s):  
H. Dugas ◽  
C. Spino ◽  
M. Ouellette
Keyword(s):  
Binding Site ◽  
Dopamine Receptor ◽  
Adrenergic Receptors ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Preliminary Results ◽  
Drug Molecules ◽  
Amino Derivatives ◽  
Derivatives Of

The syntheses of novel spin-labeled analogues of butaclamol, a spin-labeled phenylaziridinium and two amino derivatives of butaclamol, are presented. Preliminary results of in vitro activity of these compounds on dopaminergie, serotoninergic, and adrenergic receptors correlate with the importance of the previously proposed lipophilic accessory binding site in CNS dopamine receptor.

Preparation and in vitro activity of aryl ether derivatives of the FK-506 related immunosuppressive macrolides ascomycin and L-683,742

1995 ◽  
Vol 5 (10) ◽  
pp. 1035-1038 ◽  
Author(s):  
Peter J. Sinclair ◽  
Frederick Wong ◽  
Matthew Wyvratt ◽  
Mary Jo Staruch ◽  
Francis Dumont
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Aryl Ether ◽  
Fk 506 ◽  
Derivatives Of

Synthesis and in vitro activity towards Mycobacterium tuberculosis of L-serinyl ester and amino derivatives of pyrazinoic acid

2007 ◽  
Vol 2007 (3) ◽  
pp. 180-184 ◽  
Author(s):  
Alessandra C. Pinheiro ◽  
Carlos R. Kaiser ◽  
Maria C.S. LourenÇo ◽  
Marcus V.N. de Souza ◽  
Solange M.S.V. Wardell ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Amino Derivatives ◽  
Derivatives Of ◽  
Pyrazinoic Acid
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