Kinin Antagonists as Human Therapeutics

1993 ◽  
pp. 167-176
Author(s):  
E. T. Whalley ◽  
J. C. Cheronis
Keyword(s):  
Kinin Antagonists

Kinin Antagonists

1990 ◽  
Vol 15 (Supplement) ◽  
pp. S69-S74 ◽  
Author(s):  
John M. Stewart ◽  
Raymond J. Vavrek
Keyword(s):  
Kinin Antagonists

Kinin Antagonists

1990 ◽  
Vol 15 ◽  
pp. S69-S74 ◽  
Author(s):  
John M. Stewart ◽  
Raymond J. Vavrek
Keyword(s):  
Kinin Antagonists

Functional Analysis of Kinin Antagonists

1990 ◽  
Vol 15 (Supplement) ◽  
pp. S75-S77 ◽  
Author(s):  
Fred Lembeck ◽  
Thomas Griesbacher
Keyword(s):  
Functional Analysis ◽  
Kinin Antagonists

Kinin receptor antagonists: unique probes in basic and clinical research

1995 ◽  
Vol 73 (7) ◽  
pp. 797-804 ◽  
Author(s):  
Klaus J. Wirth ◽  
Hoiger Heitsch ◽  
Bernward A. Schöikens
Keyword(s):  
Clinical Studies ◽  
Tissue Injury ◽  
Chemical Properties ◽  
Density Lipoprotein ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Current Status ◽  
Suspected Sepsis ◽  
Converting Enzyme Inhibitors ◽  
Bradykinin Antagonists ◽  
Kinin Antagonists

The availability of potent and stable bradykinin antagonists has had a tremendous impact on kinin research. This article reviews the current status of research on kinin antagonists, describes their chemical properties, and delineates recent advances that have occurred with the advent of the second generation of kinin antagonists. The data collected with these antagonists support the assumption that kinins are implicated in inflammation and tissue injury as endogenous agents. Their importance, however, is not limited to the role as mediators of tissue injury and inflammation, as kinin antagonists have enabled the identification of kinins as potential endogenous cardioprotective substances, also contributing to the effects of angiotensin converting enzyme inhibitors. Clinical studies are currently being performed in asthma, postoperative pain, anaphlyactoid reactions during low density lipoprotein apheresis, systemic inflammatory response syndrome, and suspected sepsis, head injury, and hantavirus infections to investigate the utility of kinin antagonists as therapeutic agents.Key words: bradykinin antagonists, chemistry, pharmacology, basic studies, clinical studies.

The actions of kinin antagonists on B1 and B2 receptor systems

1986 ◽  
Vol 123 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Domenico Regoli ◽  
Guy Drapeau ◽  
Paolo Rovero ◽  
Stéphane Dion ◽  
Pedro D'Orléans-Juste ◽  
...  
Keyword(s):  
Kinin Antagonists

Functional Analysis of Kinin Antagonists

1990 ◽  
Vol 15 ◽  
pp. S75-S77
Author(s):  
Fred Lembeck ◽  
Thomas Griesbacher
Keyword(s):  
Functional Analysis ◽  
Kinin Antagonists
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