GABA-aminotransferase, a target for antiepileptic drug therapy

2000 ◽  
pp. 315-318
Author(s):  
Paola Storici ◽  
Guido Capitani ◽  
Daniela De Biase ◽  
Robert A. John ◽  
Johan N. Jansonius ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Gaba Aminotransferase ◽  
Antiepileptic Drug Therapy

Crystal Structure of GABA-Aminotransferase, a Target for Antiepileptic Drug Therapy†

Biochemistry ◽  
1999 ◽  
Vol 38 (27) ◽  
pp. 8628-8634 ◽  
Author(s):  
Paola Storici ◽  
Guido Capitani ◽  
Daniela De Biase ◽  
Markus Moser ◽  
Robert A. John ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Gaba Aminotransferase ◽  
Antiepileptic Drug Therapy

Specific Patient Features Affect Antiepileptic Drug Therapy Decisions: Focus on Gender, Age, and Psychiatric Comorbidities

2018 ◽  
Vol 23 (37) ◽  
pp. 5639-5648 ◽  
Author(s):  
Laura Rosa Pisani ◽  
Marina Nikanorova ◽  
Cecilie Johannessen Landmark ◽  
Svein Ivar Johannessen ◽  
Francesco Pisani
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Psychiatric Comorbidities ◽  
Specific Patient ◽  
Antiepileptic Drug Therapy

Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives

2018 ◽  
Vol 23 (37) ◽  
pp. 5760-5765 ◽  
Author(s):  
Antonio Gambardella ◽  
Angelo Labate ◽  
Laura Mumoli ◽  
Iscia Lopes-Cendes ◽  
Fernando Cendes
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Current Status ◽  
Future Perspectives ◽  
Antiepileptic Drug Therapy

scholarly journals Bone loss with antiepileptic drug therapy: a twin and sibling study

2017 ◽  
Vol 28 (9) ◽  
pp. 2591-2600 ◽  
Author(s):  
B. Shiek Ahmad ◽  
S. J. Petty ◽  
A. Gorelik ◽  
T. J. O’Brien ◽  
K. D. Hill ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Bone Loss ◽  
Antiepileptic Drug ◽  
Antiepileptic Drug Therapy ◽  
Sibling Study

Success or failure with antiepileptic drug therapy: Beyond empiricism?

Neurology ◽  
2003 ◽  
Vol 60 (2) ◽  
pp. 162-163 ◽  
Author(s):  
M. J. Brodie ◽  
J. P. Leach
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Antiepileptic Drug Therapy

Individualization of Antiepileptic Drug Therapy

1993 ◽  
pp. 109-116
Author(s):  
Y. A. Hekster ◽  
D. J. P. Wijsman ◽  
E. W. Wuis ◽  
T. B. Vree ◽  
H. Meinardi
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Antiepileptic Drug Therapy

scholarly journals Bone mineral density in children with long-term antiepileptic therapy

2013 ◽  
Vol 141 (5-6) ◽  
pp. 329-332 ◽  
Author(s):  
Milena Dimic ◽  
Aleksandar Dimic ◽  
Zoran Milosevic ◽  
Jelena Vojinovic
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Bone Mineral ◽  
Control Group ◽  
Mineral Density ◽  
Antiepileptic Therapy ◽  
Epileptic Children ◽  
Antiepileptic Drug Therapy

Introduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during long?term antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving antiepileptic drug therapy longer than one year. methods. The examined sample consisted of 34 epileptic children, 18 male and 16 female, aged 6?12 (9.77?2.01) years, treated with carbamazepine, valproate, phenobarbital, lamotrigine or their combination without vitamin D supplementation. The lumbar spine BMD (L1?L4) was estimated by a Lunar densitometer and obtained results were compared with results of 35 matched population of healthy children from the control group. results. Lumbar BMD Z?score was significantly lower in female patients treated with antiepileptic therapy compared with those in the control group (?1.048?1.35 vs. ?0.399?0.518; p=0.03). Bone mineral density Z?score decrease of both gender groups receiving antiepileptic polytherapy was significantly lower compared to the control group (?1.153?0.938 vs. ?0.043?0.815; p=0.007). Therapy duration had no influence on the lumbar BMD level decrease either in boys (rxy=0.33; p=0.174) or in girls (rxy=0.02; p=0.935) treated with antiepileptic therapy. Conclusion. Our results have indicated that antiepileptic drug therapy usage longer than one year can have adverse affects on the lumbar spine BMD (L1?L4) in epileptic children, and that prophylactic vitamin D supplementation is also necessary in these patients.

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