The isolated perfused lung

1998 ◽  
pp. 29-55 ◽  
Author(s):  
S. Uhlig
Keyword(s):  
Isolated Perfused Lung ◽  
Perfused Lung

The Effect of Tumor Necrosis Factor-?? on Microvascular Permeability in an Isolated, Perfused Lung

Shock ◽  
2002 ◽  
Vol 18 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Carl I. Schulman ◽  
Joseph K. Wright ◽  
Fiemu Nwariaku ◽  
George Sarosi ◽  
Richard H. Turnage
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Microvascular Permeability ◽  
Isolated Perfused Lung ◽  
Perfused Lung ◽  
Necrosis Factor

Effect of small doses of 5-hydroxytryptamine (serotonin) on pulmonary circulation in the closed-chest dog

1959 ◽  
Vol 197 (5) ◽  
pp. 963-967 ◽  
Author(s):  
John T. Shepherd ◽  
David E. Donald ◽  
Erland Linder ◽  
H. J. C. Swan
Keyword(s):  
Pulmonary Artery ◽  
Pulmonary Blood Flow ◽  
Pulmonary Veins ◽  
Pulmonary Vessels ◽  
Isolated Perfused Lung ◽  
Small Doses ◽  
Perfused Lung ◽  
Anesthetized Dogs ◽  
Flow Through ◽  
The Difference

5-Hydroxytryptamine (serotonin) was infused into anesthetized dogs at a rate of 20 µg/kg/min. In nine sets of observations on three dogs the increase in the difference of pressure between the pulmonary artery and the left atrium, which averaged 55%, consistently exceeded the increase in pulmonary blood flow, which averaged 16%. 5-HT therefore is a potent constrictor of pulmonary vessels, even in small concentrations. No changes in the pulmonary-artery wedge and pulmonary-vein pressures were detected during the infusions of 5-HT, nor was there any change in the volume of blood between the pulmonary artery and the root of the aorta. With this dose of 5-HT the principal site of the increased resistance to flow through the lungs appeared to be in the precapillary vessels. In the isolated perfused lung, moderate constriction of pulmonary veins also was produced by large doses of 5-HT.

Adrenomedullin activity in chronically hypoxic rat lungs

1996 ◽  
Vol 271 (2) ◽  
pp. H622-H629 ◽  
Author(s):  
L. Zhao ◽  
L. A. Brown ◽  
A. A. Owji ◽  
D. J. Nunez ◽  
D. M. Smith ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Mrna Levels ◽  
Rat Lung ◽  
Artery Pressure ◽  
Isolated Perfused Lung ◽  
Calcitonin Gene ◽  
Perfused Lung ◽  
Hypotensive Response

Adrenomedullin (AM) is a novel vasodilator with structural similarities to calcitonin gene-related peptide (CGRP). This study investigated AM activity in the rat lung during hypoxia-induced pulmonary hypertension. Both rat AM (0.2-10 nmol) and alpha-CGRP (0.2-2 nmol) produced dose-related reductions in pulmonary artery pressure in the isolated perfused lung ventilated with 2% O2. Pretreatment with alpha-CGRP, which demonstrated tachyphylaxis, or its antagonist, CGRP-(8–37), reduced the hypotensive response to AM, suggesting that part of the response to AM is mediated by CGRP receptors. 125I-labeled AM and 125I-labeled CGRP binding was significantly increased in lung membranes from 7-day hypoxic animals (AM from 1.94 +/- 0.3 to 3.36 +/- 0.4 and CGRP from 0.06 +/- 0.01 to 0.12 +/- 0.02 pmol/mg protein), with no change in dissociation constant. Moreover, the hypotensive response to both peptides was increased in the lungs of 7-day hypoxic rats. There was no significant change in lung immunoreactive AM concentrations (hypoxic 5.04 +/- 0.48 vs. control 6.28 +/- 0.76 pmol/g wet wt of tissue) or steady-state AM mRNA levels in 7-day hypoxic rats. Nonetheless, AM may be useful for the acute pharmacological manipulation of pulmonary artery pressure in hypoxia-induced pulmonary hypertension.

scholarly journals Role of potassium channels and nitric oxide in the effects of iloprost and prostaglandin E1 on hypoxic vasoconstriction in the isolated perfused lung of the rat

1997 ◽  
Vol 120 (3) ◽  
pp. 405-410 ◽  
Author(s):  
Monique Dumas ◽  
Jean-Paul Dumas ◽  
Luc Rochette ◽  
Charles Advenier ◽  
Jean-François Giudicelli
Keyword(s):  
Nitric Oxide ◽  
Potassium Channels ◽  
Prostaglandin E1 ◽  
Isolated Perfused Lung ◽  
Hypoxic Vasoconstriction ◽  
Perfused Lung
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