Multi-state Targeting Machinery Govern the Fidelity and Efficiency of Protein Localization

2013 ◽  
pp. 385-409 ◽  
Author(s):  
Mingjun Yang ◽  
Xueqin Pang ◽  
Keli Han
Keyword(s):  
Protein Localization

Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders

2012 ◽  
Vol 14 (3) ◽  
pp. 239-252
Keyword(s):  
Molecular Mechanisms ◽  
Protein Localization ◽  
Regulation Of Gene Expression ◽  
Neuronal Cell ◽  
Mrna Splicing ◽  
Genetic Mutations ◽  
Scaffolding Proteins ◽  
Molecular Processes ◽  
Genetic Studies ◽  
Novel Treatments

In this review, we outline critical molecular processes that have been implicated by discovery of genetic mutations in autism. These mechanisms need to be mapped onto the neurodevelopment step(s) gone awry that may be associated with cause in autism. Molecular mechanisms include: (i) regulation of gene expression; (ii) pre-mRNA splicing; (iii) protein localization, translation, and turnover; (iv) synaptic transmission; (v) cell signaling; (vi) the functions of cytoskeletal and scaffolding proteins; and (vii) the function of neuronal cell adhesion molecules. While the molecular mechanisms appear broad, they may converge on only one of a few steps during neurodevelopment that perturbs the structure, function, and/or plasticity of neuronal circuitry. While there are many genetic mutations involved, novel treatments may need to target only one of few developmental mechanisms.

Expression Pattern and Protein Localization of a Yellow-Green Leaf 6 (YGL6) Gene in Rice (Oryza sativa)

2018 ◽  
Vol 44 (5) ◽  
pp. 650
Author(s):  
Jun-Qiong SHI ◽  
Ya-Qin WANG ◽  
Tian-Quan ZHANG ◽  
Ling MA ◽  
Xian-chun SANG ◽  
...  
Keyword(s):  
Oryza Sativa ◽  
Expression Pattern ◽  
Protein Localization ◽  
Green Leaf
Sign in / Sign up

Export Citation Format

Share Document