On Maximal Block Functions of Computable η-like Linear Orderings

Author(s):  
Charles M. Harris
1998 ◽  
Vol 275 (3) ◽  
pp. C646-C652 ◽  
Author(s):  
Guy Droogmans ◽  
Jean Prenen ◽  
Jan Eggermont ◽  
Thomas Voets ◽  
Bernd Nilius

We have studied the effects of calix[4]arenes on the volume-regulated anion channel (VRAC) currents in cultured calf pulmonary artery endothelial cells. TS- and TS-TM-calix[4]arenes induced a fast inhibition at positive potentials but were ineffective at negative potentials. Maximal block occurred at potentials between 30 and 50 mV. Lowering extracellular pH enhanced the block and shifted the maximum inhibition to more negative potentials. Current inhibition was also accompanied by an increased current noise. From the analysis of the calix[4]arene-induced noise, we obtained a single-channel conductance of 9.3 ± 2.1 pS ( n = 9) at +30 mV. The voltage- and time-dependent block were described using a model in which calix[4]arenes bind to a site at an electrical distance of 0.25 inside the channel with an affinity of 220 μM at 0 mV. Binding occludes VRAC at moderately positive potentials, but calix[4]arenes permeate the channel at more positive potentials. In conclusion, our data suggest an open-channel block of VRAC by calix[4]arenes that also depends on the protonation of the binding site within the pore.


Order ◽  
2007 ◽  
Vol 23 (4) ◽  
pp. 321-331 ◽  
Author(s):  
Antonio Montalbán
Keyword(s):  

2010 ◽  
Vol 262 ◽  
pp. 65-81
Author(s):  
Davide Bresolin ◽  
Dario Della Monica ◽  
Valentin Goranko ◽  
Angelo Montanari ◽  
Guido Sciavicco
Keyword(s):  

1963 ◽  
Vol 6 (2) ◽  
pp. 239-255
Author(s):  
Stanton M. Trott

The model of the real numbers described below was suggested by the fact that each irrational number ρ determines a linear ordering of J2, the additive group of ordered pairs of integers. To obtain the ordering, we define (m, n) ≤ (m', n') to mean that (m'- m)ρ ≤ n' - n. This order is invariant with group translations, and hence is called a "group linear ordering". It is completely determined by the set of its "positive" elements, in this case, by the set of integer pairs (m, n) such that (0, 0) ≤ (m, n), or, equivalently, mρ < n. The law of trichotomy for linear orderings dictates that only the zero of an ordered group can be both positive and negative.


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