Biomimetic Customized Composite Scaffolds and Translational Models for the Bone Regenerative Medicine Using CAD-CAM Technology

Author(s):  
Isidoro Giorgio Lesci ◽  
Leonardo Ciocca ◽  
Norberto Roveri
2013 ◽  
Vol 21 (4) ◽  
pp. 301-308 ◽  
Author(s):  
Martin Hild ◽  
Georgios Toskas ◽  
Dilibaier Aibibu ◽  
Gretel Wittenburg ◽  
Heike Meissner ◽  
...  

Author(s):  
Xiaoli Kong ◽  
Long Chen ◽  
Bo Li ◽  
Changyun Quan ◽  
Jun Wu

Because of its ideal degradation rate and features, oxidized alginate (OA) is selected as one of the appropriate substitutes and has been introduced into hydrogels, microspheres, 3D–printed/composite scaffolds, membranes, and...


2014 ◽  
Vol 136 ◽  
pp. 393-396 ◽  
Author(s):  
L. Ciocca ◽  
D. Donati ◽  
I.G. Lesci ◽  
B. Dozza ◽  
S. Duchi ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Andréa Arruda Martins Shimojo ◽  
Amanda Gomes Marcelino Perez ◽  
Sofia Elisa Moraga Galdames ◽  
Isabela Cambraia de Souza Brissac ◽  
Maria Helena Andrade Santana

This study aimed to evaluate thein vitroperformance of activated platelet-rich plasma associated with porous sponges of chitosan as a composite scaffold for proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. The sponges were prepared by controlled freezing (−20, −80, or −196°C) and lyophilization of chitosan solutions (1, 2, or 3% w/v). The platelet-rich plasma was obtained from controlled centrifugation of whole blood and activated with calcium and autologous serum. The composite scaffolds were prepared by embedding the sponges with the activated platelet-rich plasma. The results showed the performance of the scaffolds was superior to that of activated platelet-rich plasma alone, in terms of delaying the release of growth factors and increased proliferation of the stem cells. The best preparation conditions of chitosan composite scaffolds that coordinated the physicochemical and mechanical properties and cell proliferation were 3% (w/v) chitosan and a −20°C freezing temperature, while −196°C favored osteogenic differentiation. Although the composite scaffolds are promising for regenerative medicine, the structures require stabilization to prevent the collapse observed after five days.


1997 ◽  
Vol 24 (7) ◽  
pp. 540-548 ◽  
Author(s):  
N. KAWAHATA ◽  
H. ONO ◽  
Y. NISHI ◽  
T. HAMANO ◽  
E. NAGAOKA
Keyword(s):  

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