Predicting Potential Ligands for Orphan GPCRs Based on the Improved Laplacian Regularized Least Squares Method

Author(s):  
Yan Yan ◽  
Xinwei Shao ◽  
Zhenran Jiang
2020 ◽  
Vol 123 ◽  
pp. 191-216 ◽  
Author(s):  
Chandan Gautam ◽  
Pratik K. Mishra ◽  
Aruna Tiwari ◽  
Bharat Richhariya ◽  
Hari Mohan Pandey ◽  
...  

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Fan Wang ◽  
Zhi-An Huang ◽  
Xing Chen ◽  
Zexuan Zhu ◽  
Zhenkun Wen ◽  
...  

Geophysics ◽  
2010 ◽  
Vol 75 (4) ◽  
pp. S131-S137 ◽  
Author(s):  
Yanfei Wang ◽  
Changchun Yang

New solution methods were considered for migration deconvolution in seismic imaging problems. It is well known that direct migration methods, using the adjoint operator [Formula: see text], yield a lower-resolution or blurred image, and that the linearized inversion of seismic data for the reflectivity model usually requires solving a (regularized) least-squares migration problem. We observed that the (regularized) least-squares method is computationally expensive, which becomes a severe obstacle for practical applications. Iterative gradient-descent methods were studied and an efficient method for migration deconvolution was developed. The problem was formulated by incorporating regularizing constraints, and then a nonmonotone gradient-descent method was applied to accelerate the convergence. To test the potential of the application of the developed method, synthetic two-dimensional and three-dimensional seismic-migration-deconvolution simulations were performed. Numerical performance indicates that this method is promising for practical seismic migration imaging.


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