This paper is interested in raising the question to which extent the epistemological implications of the Mode 3 concept coincide with the respective knowledge understanding. The argumentation focuses on the article from David F. J. Campbell and Elias G. “Mode 3” and “Quadruple Helix”: Toward a 21st Century Fractal Innovation Ecosystem (2009) and aims to illuminate it from a theoretical perspective. The starting point is the elaborated basic understanding of knowledge as well as the interpretation of knowledge production.