TRP Channels in Cold Transduction

2015 ◽  
pp. 185-207 ◽  
Author(s):  
Alejandro González ◽  
Gonzalo Ugarte ◽  
Ricardo Piña ◽  
María Pertusa ◽  
Rodolfo Madrid
Keyword(s):  
Trp Channels

Possible Involvement of TRP Channels in Cardiac Hypertrophy and Arrhythmia

2013 ◽  
Vol 13 (3) ◽  
pp. 283-294 ◽  
Author(s):  
Hiroyuki Watanabe ◽  
Kenji Iino ◽  
Takayoshi Ohba ◽  
Hiroshi Ito
Keyword(s):  
Cardiac Hypertrophy ◽  
Trp Channels

Pharmacology of TRP Channels in the Vasculature

2013 ◽  
Vol 11 (4) ◽  
pp. 480-489 ◽  
Author(s):  
Isaac Jardin ◽  
Natalia Dionisio ◽  
Jose Lopez ◽  
Gines Salido ◽  
Juan Rosado
Keyword(s):  
Trp Channels

scholarly journals Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation?

2014 ◽  
Vol 15 (9) ◽  
pp. 16430-16457 ◽  
Author(s):  
Seung-In Choi ◽  
Sungjae Yoo ◽  
Ji Lim ◽  
Sun Hwang
Keyword(s):  
Lipid Peroxidation ◽  
Trp Channels

TRP Channels in Cancer Pain

2021 ◽  
pp. 174185
Author(s):  
Amanda Spring de Almeida ◽  
Laura de Barros Bernardes ◽  
Gabriela Trevisan
Keyword(s):  
Cancer Pain ◽  
Trp Channels

scholarly journals New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice

2021 ◽  
Author(s):  
Saied Froghi ◽  
Charlotte R. Grant ◽  
Radhika Tandon ◽  
Alberto Quaglia ◽  
Brian Davidson ◽  
...  
Keyword(s):  
Immune System ◽  
Calcium Release ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Calcium Influx ◽  
Calcium Signalling ◽  
Chronic Fatigue ◽  
Diverse Range ◽  
Immune System Activation

AbstractCalcium is the most abundant mineral in the human body and is central to many physiological processes, including immune system activation and maintenance. Studies continue to reveal the intricacies of calcium signalling within the immune system. Perhaps the most well-understood mechanism of calcium influx into cells is store-operated calcium entry (SOCE), which occurs via calcium release-activated channels (CRACs). SOCE is central to the activation of immune system cells; however, more recent studies have demonstrated the crucial role of other calcium channels, including transient receptor potential (TRP) channels. In this review, we describe the expression and function of TRP channels within the immune system and outline associations with murine models of disease and human conditions. Therefore, highlighting the importance of TRP channels in disease and reviewing potential. The TRP channel family is significant, and its members have a continually growing number of cellular processes. Within the immune system, TRP channels are involved in a diverse range of functions including T and B cell receptor signalling and activation, antigen presentation by dendritic cells, neutrophil and macrophage bactericidal activity, and mast cell degranulation. Not surprisingly, these channels have been linked to many pathological conditions such as inflammatory bowel disease, chronic fatigue syndrome and myalgic encephalomyelitis, atherosclerosis, hypertension and atopy.

Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses

2011 ◽  
Vol 110 (3) ◽  
pp. 789-798 ◽  
Author(s):  
Kaori Ono ◽  
Masako Tsukamoto-Yasui ◽  
Yoshiko Hara-Kimura ◽  
Naohiko Inoue ◽  
Yoshihito Nogusa ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Low Frequency ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Intragastric Administration ◽  
Brown Adipose ◽  
Reflex Arc ◽  
Transient Receptor

The sympathetic thermoregulatory system controls the magnitude of adaptive thermogenesis in correspondence with the environmental temperature or the state of energy intake and plays a key role in determining the resultant energy storage. However, the nature of the trigger initiating this reflex arc remains to be determined. Here, using capsiate, a digestion-vulnerable capsaicin analog, we examined the involvement of specific activation of transient receptor potential (TRP) channels within the gastrointestinal tract in the thermogenic sympathetic system by measuring the efferent activity of the postganglionic sympathetic nerve innervating brown adipose tissue (BAT) in anesthetized rats. Intragastric administration of capsiate resulted in a time- and dose-dependent increase in integrated BAT sympathetic nerve activity (SNA) over 180 min, which was characterized by an emergence of sporadic high-activity phases composed of low-frequency bursts. This increase in BAT SNA was abolished by blockade of TRP channels as well as of sympathetic ganglionic transmission and was inhibited by ablation of the gastrointestinal vagus nerve. The activation of SNA was delimited to BAT and did not occur in the heart or pancreas. These results point to a neural pathway enabling the selective activation of the central network regulating the BAT SNA in response to a specific stimulation of gastrointestinal TRP channels and offer important implications for understanding the dietary-dependent regulation of energy metabolism and control of obesity.

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