Stem Cell Therapy for Autoimmune Disease

2016 ◽  
pp. 225-248
Author(s):  
Phuc Van Pham
Keyword(s):  
Stem Cell ◽  
Autoimmune Disease ◽  
Cell Therapy ◽  
Stem Cell Therapy

Mesenchymal Stem Cell Therapy for Autoimmune Disease: Risks and Rewards

2015 ◽  
Vol 24 (18) ◽  
pp. 2091-2100 ◽  
Author(s):  
Hafsa Munir ◽  
Helen M. McGettrick
Keyword(s):  
Stem Cell ◽  
Autoimmune Disease ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Disease Risks

scholarly journals Stem cell therapy for autoimmune disease: overview of concepts from the Snowbird 2002 tolerance and tissue regeneration meeting

2003 ◽  
Vol 32 (S1) ◽  
pp. S3-S5 ◽  
Author(s):  
R K Burt ◽  
R Arnold ◽  
R Emmons ◽  
Y Oyama ◽  
A Marmont
Keyword(s):  
Stem Cell ◽  
Autoimmune Disease ◽  
Cell Therapy ◽  
Tissue Regeneration ◽  
Stem Cell Therapy

scholarly journals Adult Stem Cell Therapy for Autoimmune Disease

2009 ◽  
Vol 2 (2) ◽  
pp. 122-128 ◽  
Author(s):  
Eun Wha Choi
Keyword(s):  
Stem Cell ◽  
Autoimmune Disease ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Adult Stem Cell

Hematopoietic stem cell transplantation in systemic sclerosis: Yes!! BUT. . .

2020 ◽  
pp. 239719832097196
Author(s):  
Khitam A AlOdhaibi ◽  
John Varga ◽  
Daniel E Furst
Keyword(s):  
Clinical Trials ◽  
Stem Cell ◽  
Systemic Sclerosis ◽  
Autoimmune Disease ◽  
Cell Therapy ◽  
Stem Cell Transplantation ◽  
Immunosuppressive Therapy ◽  
Hematopoietic Stem Cell ◽  
Stem Cell Therapy ◽  
Hematopoietic Stem

Systemic sclerosis is a chronic multisystem, autoimmune disease with high mortality, and to date, has no effective approved therapy. For patients with the most severe forms of systemic sclerosis, autologous hematopoietic stem cell therapy has been proven to be effective, as demonstrated by three randomized controlled clinical trials and at least two registry studies. In the controlled studies, autologous hematopoietic stem cell therapy was shown to improve mortality, skin involvement, quality-of-life, and function compared with patients treated with intravenous cyclophosphamide. There is significant transplant-related mortality associated with autologous hematopoietic stem cell therapy, as well as infectious and noninfectious serious adverse events, including cardiac and renal compromise. Although the results of autologous hematopoietic stem cell therapy clinical trials to date are highly encouraging, a number of important unanswered questions remain. These include the following: What is the optimal transplant regimen; can the spectrum of systemic sclerosis patients who respond to autologous hematopoietic stem cell therapy be expanded; how can disease relapse following autologous hematopoietic stem cell therapy be predicted and managed; can treatment-related toxicity and mortality be mitigated; can response or toxicity be predicted; and finally, is there a place for allogeneic stem cell transplants in systemic sclerosis? Systemic sclerosis is an autoimmune disease with multiple immunological, vascular, and fibrotic abnormalities. Immunosuppressive therapy is frequently used, but to date its efficacy has been generally modest. Stem cell transplantation is the most potent immunosuppressive therapy currently available, and as discussed below, may have an important role in the management of systemic sclerosis.

Stem Cell Therapy for Autoimmune Disease

2019 ◽  
Author(s):  
Richard K. Burt ◽  
Alberto M. Marmont
Keyword(s):  
Stem Cell ◽  
Autoimmune Disease ◽  
Cell Therapy ◽  
Stem Cell Therapy

Stem Cell Therapy During CABG Improves Ejection Fraction

2008 ◽  
Vol 6 (3) ◽  
pp. 36
Author(s):  
NANCY WALSH
Keyword(s):  
Stem Cell ◽  
Ejection Fraction ◽  
Cell Therapy ◽  
Stem Cell Therapy
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