Thoracic Air Leaks

2016 ◽  
pp. 665-672
Author(s):  
Jennifer R. Bermick ◽  
Steven M. Donn
Keyword(s):  
Air Leaks

scholarly journals Bio-artificial pleura using autologous dermal fibroblast sheets to mitigate air leaks during thoracoscopic lung resection

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Masato Kanzaki ◽  
Ryo Takagi ◽  
Kaoru Washio ◽  
Mami Kokubo ◽  
Shota Mitsuboshi ◽  
...  
Keyword(s):  
Dermal Fibroblast ◽  
Lung Resection ◽  
Fibroblast Cell ◽  
Patient Specific ◽  
Cell Content ◽  
Cell Monolayers ◽  
Air Leaks ◽  
Skin Biopsies ◽  
Dermal Cells ◽  
Lung Resections

AbstractLung air leaks (LALs) due to visceral pleura injury during surgery are a difficult-to-avoid complication in thoracic surgery (TS). Reliable LAL closure is an important patient management issue after TS. We demonstrated both safeties of transplantation of a cultured human autologous dermal fibroblast sheet (DFS) to LALs. From May 2016 to March 2018, five patients who underwent thoracoscopic lung resection met all the inclusion criteria. Skin biopsies were acquired from each patient to source autologous dermal cells for DFS fabrication. During the primary culture, fibroblasts migrated from the dermal tissue pieces and proliferated to form cell monolayers. These fibroblasts were subcultured to confluence. Transplantable DFSs were fabricated from these subcultured fibroblasts that were trypsinized and seeded onto temperature-responsive culture dishes. After 10 days of fabrication culture, intact patient-specific DFS were harvested. DFSs were analyzed for fibroblast cell content and tissue contaminants prior to application. For closing intraoperative LAL, mean number of transplanted autologous DFS per patient was 6 ± 2 sheets. Mean chest drainage duration was 5.0 ± 4.8 days. The two patients with major LAL had a drainage duration of more than 7 days. All patients currently have no LAL recurrence after discharge. DFSs effectively maintain LAL closure via remodeling of the deposited extracellular matrix. The use of autologous DFSs to permanently close air leaks using a patient-derived source is expected to reduce surgical complications during high-risk lung resections.

Management of Persistent Air Leaks with Intrabronchial Valves

2017 ◽  
Vol 66 (07) ◽  
pp. 603-606
Author(s):  
Andreas Hecker ◽  
Konstantin Mayer ◽  
Biruta Witte ◽  
Matthias Hecker
Keyword(s):  
Thoracic Surgery ◽  
Minimal Invasive ◽  
Therapeutic Approaches ◽  
Air Leak ◽  
Frequent Complication ◽  
Less Invasive ◽  
Air Leaks ◽  
Prolonged Hospitalization ◽  
Highly Effective ◽  
Endoscopic Placement

AbstractPersistent air leaks (PALs) are regarded as a frequent complication after thoracic surgery resulting in prolonged hospitalization and increased morbidity. Several more or less invasive therapeutic approaches are available for treatment of PAL with varying degrees of success. The endoscopic placement of one-way intrabronchial valves in the segment(s) in which the air leak has been located offers a highly effective and well-tolerated minimal invasive option for patients with PAL.

scholarly journals Intrabronchial Valve Treatment for Prolonged Air Leak: Can We Justify the Cost?

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Eitan Podgaetz ◽  
Felix Zamora ◽  
Heidi Gibson ◽  
Rafael S. Andrade ◽  
Eric Hall ◽  
...  
Keyword(s):  
Individual Patient Data ◽  
Cost Effective ◽  
Air Leak ◽  
Levels Of Care ◽  
Air Leaks ◽  
Limited Experience ◽  
Tube Removal ◽  
Prolonged Air Leak ◽  
Chest Tube Removal ◽  
The Cost

Background.Prolonged air leak is defined as an ongoing air leak for more than 5 days. Intrabronchial valve (IBV) treatment is approved for the treatment of air leaks.Objective.To analyze our experience with IBV and valuate its cost-effectiveness.Methods.Retrospective analysis of IBV from June 2013 to October 2014. We analyzed direct costs based on hospital and operating room charges. We used average costs in US dollars for the analysis not individual patient data.Results.We treated 13 patients (9 M/4 F), median age of 60 years (38 to 90). Median time from diagnosis to IBV placement was 9.8 days, time from IBV placement to chest tube removal was 3 days, and time from IBV placement to hospital discharge was 4 days. Average room and board costs were $14,605 including all levels of care. IBV cost is $2750 per valve. The average number of valves used was 4. Total cost of procedure, valves, and hospital stay until discharge was $13,900.Conclusion.In our limited experience, the use of IBV to treat prolonged air leaks is safe and appears cost-effective. In pure financial terms, the cost seems justified for any air leak predicted to last greater than 8 days.

Management of Air Leaks

1977 ◽  
Vol 23 (2) ◽  
pp. 194
Author(s):  
John S. McCabe
Keyword(s):  
Air Leaks

Pneumomediastinum in the Neonate

2014 ◽  
Vol 33 (5) ◽  
pp. 275-282 ◽  
Author(s):  
Kristi J. Cagle ◽  
Carol Trotter
Keyword(s):  
Air Leak ◽  
Air Leaks ◽  
Radiologic Findings ◽  
Free Air

A pneumomediastinum is an air leak in which the free air is concentrated in the mediastinum. Although most neonatal pneumomediastinums do not require intervention, complications such as subsequent air leaks can arise. Proper radiologic identification, as well as an understanding of the anatomy and pathophysiology associated with a pneumomediastinum, are necessary for an accurate understanding and diagnosis. This article will review the interpretation of radiologic findings in a neonate with a pneumomediastinum.

Digital thoracic drainage: a new system to monitor air leaks in pediatric population

2019 ◽  
Vol 54 (4) ◽  
pp. 693-695 ◽  
Author(s):  
Laura Pérez-Egido ◽  
María Antonia García-Casillas ◽  
Isabel Simal ◽  
María Fanjul ◽  
Agustin Cañizo ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Air Leaks ◽  
Thoracic Drainage ◽  
New System

Efficacy and long-term clinical outcome of bronchial occlusion with endobronchial Watanabe spigots for persistent air leaks

2015 ◽  
Vol 53 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Hiroyuki Kaneda ◽  
Ken-ichiro Minami ◽  
Takahito Nakano ◽  
Yohei Taniguchi ◽  
Tomohito Saito ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Air Leaks

Peritoneal Free Autologous Fat Graft for the Control of Pulmonary Air Leaks in Emphysematous Rat Lungs

2014 ◽  
Vol 98 (1) ◽  
pp. 271-276 ◽  
Author(s):  
Cristiano F. Andrade ◽  
Eduardo Fontena ◽  
Paulo F.G. Cardoso ◽  
Raôni B. Pereira ◽  
Gustavo Grun ◽  
...  
Keyword(s):  
Fat Graft ◽  
Autologous Fat ◽  
Air Leaks ◽  
Rat Lungs ◽  
Autologous Fat Graft

The Prevention and Management of Air Leaks Following Pulmonary Resection

2015 ◽  
Vol 25 (4) ◽  
pp. 411-419 ◽  
Author(s):  
Bryan M. Burt ◽  
Joseph B. Shrager
Keyword(s):  
Pulmonary Resection ◽  
Air Leaks
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