Neural Control of Cardiac Function in Health and Disease

2016 ◽  
pp. 13-35 ◽  
Author(s):  
Pradeep S. Rajendran ◽  
Ray W. Chui ◽  
Olujimi A. Ajijola ◽  
Marmar Vaseghi ◽  
J. Andrew Armour ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Neural Control ◽  
Health And Disease

Cardiac Function in Health and Disease

1970 ◽  
Vol 50 (2) ◽  
pp. 300-301
Author(s):  
Don Lehmkuhl
Keyword(s):  
Cardiac Function ◽  
Health And Disease

Neural control of renal function in health and disease

1994 ◽  
Vol 4 (1-2) ◽  
pp. 69-74 ◽  
Author(s):  
Gerald F. DiBona
Keyword(s):  
Renal Function ◽  
Neural Control ◽  
Health And Disease

P3509Leukocyte derived tumour necrosis factor modulates cardiac function in health and disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Walker ◽  
A Gutierrez Del Arroyo ◽  
J Sanchez ◽  
G L Ackland
Keyword(s):  
Ejection Fraction ◽  
Cardiac Function ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Cardiac Injury ◽  
Cardiac Cells ◽  
Health And Disease ◽  
Deficient Mice ◽  
Necrosis Factor

Abstract Purpose Tumour necrosis factor alpha (TNFα) regulates both normal and pathophysiological cardiac function. The regulatory role of TNFα derived from different sources (leukocyte versus cardiac cells) in cardiac physiology is unclear. Deficiency of iRhom2 protein prevents circulating immune cells from shedding TNFα (and CD62L, an adhesion molecule essential for effective immune function). Here we investigated the role of leukocyte derived TNFα in constitutive cardiac function and after cardiac injury. Methods Adult iRhom2-deficient mice (KO) and wildtype (Wt) littermates, of both genders, underwent echocardiography to assess cardiac physiologic function at least 1 week before receiving a single dose of isoproterenol (300mg/kg IP) to induce cellular death in 10% of the cardiomyoctes [1]. Cardiac echocardiography was repeated 36 hours after isoproterenol. Peripheral and cardiac-resident leukocytes were phenotyped by flow cytometry and molecular markers of cardiac stress (atrial and brain natriuretic protein, ANP, BNP) and inflammation (NFkB) were quantified using RT-PCR. Results Peripheral leukocytes from iRhom2 KO mice failed to shed CD62L in response to isoproterenol induced cardiac injury (e.g. neutrophils CD62L Mean Fluorescence Intensity KO: 9149±4616, Wt: 972±558, p<0.0001, n=9). iRhom2-deficient mice had higher cardiac output at baseline (KO 23±2 mL/min, n=11) compared to their wildtype littermates (Wt 18±3 mL/min, n=9). Wild type mice increased contractility after isoproterenol (Wt ejection fraction: baseline 60±6%, isoproterenol 68±6%, n=8) whilst iRhom2-deficient mice were unable to (KO ejection fraction: baseline 66±9%, isoproterenol 61±5%, n=8). ANP and BNP mRNA were elevated in ventricular tissue of iRhom2-knockout mice after isoproterenol, when compared to naïve tissue (ANP 2ΔCT: 3x increase, BNP 2ΔCT: 1.6x increase) whereas only ANP was elevated in wildtypes (ANP 2ΔCT: 2.7x increase, BNP 2ΔCT: 0.9x increase). No difference in immune cell infiltration of ventricular cardiac tissue was observed (number of CD45+ cells KO: 3014±3482, Wt: 2555±1411, p=0.7, n=9) NFkB mRNA was upregulated at baseline (2ΔCT KO: 0.2±0.08, Wt: 0.1±0.09) suggesting constitutive cardiac inflammation in iRhom2-deficient mice. Conclusions Inability to shed CD62L and TNFα is associated with constitutive and acquired cardiac dysfunction in iRhom2-deficient mice. These data support the hypothesis that leukocyte-derived TNFα is required for maintaining cardiac function in health and disease. Acknowledgement/Funding National Institute of Academic Anaesthesia/Royal College of Anaesthetists/British Journal of Anaesthesia; National Institute for Health Research

The Role of CaM Kinase II in Cardiac Function in Health and Disease

2012 ◽  
pp. 447-461
Author(s):  
Adriana Adameova ◽  
Adrian Szobi ◽  
Slavka Carnicka ◽  
Tanya Ravingerova ◽  
Tomas Rajtik
Keyword(s):  
Cardiac Function ◽  
Cam Kinase Ii ◽  
Cam Kinase ◽  
Health And Disease

Purinergic modulation of neural control of cardiac function

1996 ◽  
Vol 16 (6) ◽  
pp. 401-406 ◽  
Author(s):  
A. Pelleg ◽  
G. Katchanov ◽  
J. Xu
Keyword(s):  
Cardiac Function ◽  
Neural Control ◽  
Purinergic Modulation
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