Biphasic Dose–Response Phenomenon Induced by Xenobiotics and Its Application in Soil Risk Assessment

2017 ◽  
pp. 125-138
Author(s):  
Muhammad Zaffar Hashmi ◽  
Adeel Mehmood ◽  
Sohaib Khan ◽  
Ahmad Hasnain ◽  
Zulkifl Ahmed
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Soil Risk Assessment ◽  
Biphasic Dose Response

A new model for polluted soil risk assessment

2006 ◽  
Vol 32 (7) ◽  
pp. 890-896 ◽  
Author(s):  
M. Andretta ◽  
R. Serra ◽  
M. Villani
Keyword(s):  
Risk Assessment ◽  
Polluted Soil ◽  
New Model ◽  
Soil Risk Assessment

Hormesis is central to toxicology, pharmacology and risk assessment

2010 ◽  
Vol 29 (4) ◽  
pp. 249-261 ◽  
Author(s):  
Edward J Calabrese
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Low Dose ◽  
Assessment Practices ◽  
Biological Organization ◽  
Setting Process ◽  
Toxicological Research ◽  
Multiple Levels ◽  
Dose Responses ◽  
Chemical Class

This paper summarizes numerous conceptual and experimental advances over the past two decades in the study of hormesis. Hormesis is now generally accepted as a real and reproducible biological phenomenon, being highly generalized and independent of biological model, endpoint measured and chemical class/physical stressor. The quantitative features of the hormetic dose response are generally highly consistent, regardless of the model and mechanism, and represent a quantitative index of biological plasticity at multiple levels of biological organization. The hormetic dose-response model has been demonstrated to make far more accurate predictions of responses in low dose zones than either the threshold or linear at low dose models. Numerous therapeutic agents widely used by humans are based on the hormetic dose response and its low dose stimulatory characteristics. It is expected that as low dose responses come to dominate toxicological research that risk assessment practices will incorporate hormetic concepts in the standard setting process.

Improving the Development and Use of Biologically Based Dose Response Models (BBDR) in Risk Assessment

2001 ◽  
Vol 7 (5) ◽  
pp. 1091-1120 ◽  
Author(s):  
Robert S. DeWoskin ◽  
Stan Barone ◽  
Harvey J. Clewell ◽  
R. Woodrow Setzer
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Response Models
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