RAGE Exacerbate Amyloid Beta (Aβ) Induced Alzheimer Pathology: A Systemic Overview

2019 ◽  
pp. 159-170
Author(s):  
Firoz Akhter ◽  
Asma Akhter ◽  
Kavindra Kumar Kesari ◽  
Ruheena Javed ◽  
Janne Ruokolainen ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Alzheimer Pathology

scholarly journals Hook Proteins: Association with Alzheimer Pathology and Regulatory Role of Hook3 in Amyloid Beta Generation

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119423 ◽  
Author(s):  
Lydia Herrmann ◽  
Caspar Wiegmann ◽  
Annika Arsalan-Werner ◽  
Isabel Hilbrich ◽  
Carsten Jäger ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Regulatory Role ◽  
Alzheimer Pathology

scholarly journals APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

2010 ◽  
Vol 67 (1) ◽  
pp. 122-131 ◽  
Author(s):  
John C. Morris ◽  
Catherine M. Roe ◽  
Chengjie Xiong ◽  
Anne M. Fagan ◽  
Alison M. Goate ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Normal Aging ◽  
Cognitively Normal ◽  
Alzheimer Pathology

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

Mitochondrial failure precedes amyloid beta plaques deposition in APP transgenic mice

2005 ◽  
Vol 38 (05) ◽  
Author(s):  
A Eckert ◽  
I Scherping ◽  
A Bonert ◽  
S Hauptmann ◽  
F Müller-Spahn ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Beta
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