Extracting Sequential Patterns for Gene Regulatory Expressions Profiles

2004 ◽  
pp. 46-57 ◽  
Author(s):  
Doru Tanasa ◽  
Jesús A. López ◽  
Brigitte Trousse
Keyword(s):  
Sequential Patterns ◽  
Gene Regulatory

How do histone modifications contribute to transgenerational epigenetic inheritance in C. elegans?

2020 ◽  
Vol 48 (3) ◽  
pp. 1019-1034 ◽  
Author(s):  
Rachel M. Woodhouse ◽  
Alyson Ashe
Keyword(s):  
Histone Modifications ◽  
Molecular Mechanisms ◽  
Epigenetic Inheritance ◽  
Nematode Caenorhabditis Elegans ◽  
Histone Methyltransferases ◽  
Transgenerational Epigenetic Inheritance ◽  
C Elegans ◽  
Recent Developments ◽  
Gene Regulatory

Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful in investigating the underlying molecular mechanisms of this phenomenon. In C. elegans and other animals, the modification of histone proteins has emerged as a potential carrier and effector of transgenerational epigenetic information. In this review, we explore the contribution of histone modifications to TEI in C. elegans. We describe the role of repressive histone marks, histone methyltransferases, and associated chromatin factors in heritable gene silencing, and discuss recent developments and unanswered questions in how these factors integrate with other known TEI mechanisms. We also review the transgenerational effects of the manipulation of histone modifications on germline health and longevity.

Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

2009 ◽  
Vol 138 (1) ◽  
pp. 172-185
Author(s):  
Ben Emery ◽  
Dritan Agalliu ◽  
John D. Cahoy ◽  
Trent A. Watkins ◽  
Jason C. Dugas ◽  
...  
Keyword(s):  
Transcriptional Regulator ◽  
Regulatory Factor ◽  
Gene Regulatory ◽  
Cns Myelination ◽  
Myelin Gene

2061-P: Islet Single Cell Transcriptomes Reveal Cellular and Gene Regulatory Alterations in Type 2 Diabetes Pathogenesis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2061-P
Author(s):  
NATHAN LAWLOR ◽  
ROMY KURSAWE ◽  
MICHAEL L. STITZEL
Keyword(s):  
Type 2 Diabetes ◽  
Single Cell ◽  
Gene Regulatory
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